Evaluasi Penggunaan Antibiotik pada Pasien Sepsis Neonatus di Rumah Sakit X Purwakarta

Abstract

Abstract Background: The high morbidity and mortality rates in neonates are caused by sepsis. Bacteria is one of the causes, so that antibiotics are one of the empirical therapies. Irrational use of antibiotics can cause bacteria to become resistant, so that the goal of therapy is not optimal. Objectives: This study aimed to evaluate the antibiotics used by neonatal sepsis patients in terms of quality (Gyssens method) and quantity (Defined Daily Dose method) and to determine the relationship between drug rationale and length of stay using the Spearman Rank correlation test. Methods: This research was observational research with a Cross-sectional designed and analysed using the descriptive-analytic method. Prospective patient data collection from May-July 2019 obtained 67 medical records that met the inclusion criteria. Results: The evaluation of the quality of antibiotics, it was found that 26 patients (37.7%) of the use of appropriate antibiotics were correct and 43 patients were incorrect, including 56.5% inaccurate doses of antibiotics, 4.3% because there were other antibiotics that were more effective and 1.4% the existence of antibiotics too long while the quantity of antibiotics use was 12.9 DDD/100 patient days including Ampicilin Sulbactam (3.25), Cefoperazone Sulbactam (4), Meropenem (2.42) while the value DDD exceeding WHO standard values were gentamicin (1.94) and Amikacin (1.29). Correlation results found r = 0.223 (P ≥ 0.05), indicating that the correlation between rational use of drugs with the length of stay was low. Conclusion: Inappropriate use of antibiotics still exists with quantities exceeding WHO standards. Keywords: neonatal sepsis, antibiotics, gyssens method, DDD (defined daily dose) method, rank Spearman