Non-typhoidal Salmonella infections across India: emergence of a neglected group of enteric pathogens

Abstract

Objective: Non-typhoidal Salmonellae (NTS) are a neglected group of enteric pathogens whose prevalence is increasing at alarming rates across India. The disease burden is being underestimated because of a lack of effective surveillance of NTS infections in the Indian population. This study depicts the acquisition of NTS infection, and its persistence and spread through a diverse range of hosts, including humans and animals, and food and environmental sources. Methods: During the study period from 2016 to 2018, a total of 999 suspected NTS isolates were received from across India and were phenotypically and serologically characterized for the presence of NTS. Results: Of the 999 isolates, 539 (53.95%) were confirmed as NTS, consisting of 17 different NTS serovars. The majority were isolated from human samples (n ¼ 319, 59.18%), followed by food products (n ¼ 99, 18.37%), animals (n ¼ 83, 15.4%) and the environment (n ¼ 38, 7.05%). Some predominant serovars obtained included S. Typhimurium (n ¼ 167, 30.98%), S. Lindenberg (n ¼ 135, 25.05%), S. Enteritidis (n ¼ 56, 10.39%), S. Weltevreden (n ¼ 44, 8.16%), S. Choleraesuis (n ¼ 41, 7.61%) and S. Mathura (n ¼ 33, 6.12%). Conclusion: This study depicts the NTS disease burden across India, on the basis of the isolation of NTS serovars across diverse geographic locations. The emergence of newer or less common NTS serovars implicated in human infection poses a potential challenge to the healthcare system in India. Therefore, national and regional level surveillance is needed to implement effective control strategies and safeguard community health in India.