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Title: | Amelioration of the hepatotoxic effects of nonsteroidal drugs using vitamin C and determination of their relationship with the lipid profile |
Authors: | Al-Hayder, Manal N. Aledani, Tamadir H.W. Al-Mayyahi, Rawaa S. |
Keywords: | Hepatotoxicity Histopathology Lipid profile Nonsteroidal anti-inflammatory drugs Vitamin C |
Issue Date: | 2022 |
Publisher: | Journal of Taibah University Medical Sciences |
Series/Report no.: | Original Article;715-723 |
Abstract: | Objective: Despite the various clinical benefits of nonsteroidal anti-inflammatory drugs, their frequent and prolonged use has led to numerous health risks, including hepatotoxicity. Hepatotoxicity mediated by oxidative stress can affect the lipid profile. The objective was to investigate whether post-treatment with vitamin C can ameliorate the effects of diclofenac and naproxen in the livers of prepubertal rats and to highlight their relationship with lipid profile. Methods: Forty prepubertal female albino rats were distributed among the control group, the diclofenacadministered group (5 mg/kg/day), and the naproxenadministered group (50 mg/kg/day). This study included two phases. In Phase 1, only five rats from each group were dissected after 21 days of oral administration to assess the hepatotoxic effects of nonsteroidal drugs. In Phase 2, five of the remaining animals in each intervention group were post-treated with 25 mg/kg/day of vitamin C for an additional 21 days. After the administration and post-treatment, serum biochemical parameters and histopathological signs were evaluated. Results: Extreme elevation in the levels of aspartate and alanine aminotransferases was observed in the diclofenac and naproxen groups compared with those in the control (p < 0.001). In addition, the levels of high- and lowdensity lipoproteins were significantly impacted in these drug groups (p < 0.01, p < 0.05 respectively). Several pathological signs in the liver histology were observed in both drug groups. After post-treatment with vitamin C, noticeable amelioration of these alterations was observed. There were slightly elevation in the liver enzymes and insignificant increase and decrease in the high and lowdensity lipoproteins respectively. Conclusion: Vitamin C post-treatment ameliorated the hepatotoxicity induced by diclofenac sodium and naproxen. |
URI: | http://localhost:8080/xmlui/handle/123456789/7295 |
ISSN: | 1658-3612 |
Appears in Collections: | Vol 17 No 4 (2022) |
Files in This Item:
File | Description | Size | Format | |
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715-723.pdf | 715-723 | 3.12 MB | Adobe PDF | View/Open |
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