Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7249
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNeekhra, Sachin-
dc.contributor.authorAwasthi, Himani-
dc.contributor.authorPrasad Singh, Dharmchand-
dc.date.accessioned2024-11-02T03:33:54Z-
dc.date.available2024-11-02T03:33:54Z-
dc.date.issued2021-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/7249-
dc.description.abstractBackground: Stress is the causative factor for various diseases and disorders faced by the majority of the diseased population. The leaves of Sambucus nigra (S. nigra) are attributed to neuropharmacological properties as per literature. Considering the above, the S. nigra hydroalcoholic extract was tested for adaptogenic activity in animals. Objective: The study deals with the evaluation of S. nigra hydroalcoholic extract for adaptogenic activity using cold immobilization and footshock induced stress. Materials and Methods: The S. nigra hydroalcoholic extract (200 and 400 mg/kg) was administered to treatment groups 1 hour before footshock for 14 consecutive days and cold immobilization stress for 10 consecutive days, respectively. The current work was carrying out to investigate the adaptogenic activity of S. nigra against footshock stress induced perturbations in behaviour (sexual behaviour, depression, and cognitive dysfunction). Suppressed male sexual behaviour, percentage active avoidance response and duration of immobility in footshock stress were used as the stress indices. Additionally, liver function (SGOT, SGPT, and ALP), lipid profiles (TC, TG, HDL, LDL, and VLDL) and differential leukocytes counts (neutrophils, eosinophils, lymphocyte, and monocyte) in cold immobilization stress were assessed in terms of stress indices. Diazepam (1 mg/kg) was served as the standard adaptogenic agent as per literature review for comparison. Results: All these chronic stress-induced perturbations were reversed, dose-dependently by S. nigra (2000 and 400 mg/kg) and diazepam (1 mg/kg). The dose group 400 mg/kg p.o. of S. nigra hydroalcoholic extract for adaptogenic activity in cold immobilization and footshock induced stress method showed significant variation (P< 0.1) when is compared with the stress control group. Conclusion: S. nigra hydroalcoholic extract showed significant adaptogenic activity was indicated by qualitatively results comparable to diazepam, against a range of biochemical and behavioural perturbations induced by chronic stress. Key words: Active avoidance response; Cold immobilization; Footshock induced stress; Lipid profiles; Sexual behaviour; Sambucus nigra.en_US
dc.subjectActive avoidance responseen_US
dc.subjectCold immobilizationen_US
dc.subjectFootshock induced stressen_US
dc.subjectLipid profilesen_US
dc.subjectSexual behaviouren_US
dc.subjectSambucus nigraen_US
dc.titleBeneficial Effects of Sambucus nigra in Chronic Stress-Induced Neurobehavioral and Biochemical Perturbation in Rodentsen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 1 2021

Files in This Item:
File Description SizeFormat 
23.pdf466.99 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.