Optimasi Aristoflex®️ AVC dan Propilen Glikol Gel Tabir Surya Rimpang Kunyit dengan Metode Desain Faktorial

Abstract

Abstract Background: Turmeric (Curcuma domestica) contains curcumin suitable for use as a skin protector from ultraviolet (UV). Topical sunscreens need to be developed, which is a gel, the most stable preparation. Optimization is more profitable than trial and error methods in terms of cost, time, and accuracy of results. Objective: To determine the effect of combining Aristoflex® AVC and propylene glycol on the physical properties of turmeric rhizome extract gel, as well as the optimum turmeric rhizome extract gel formula and the effect of combining Aristoflex® AVC and propylene glycol on the SPF value of turmeric rhizome extract gel. Methods: Gel had been made into four formulas with the composition of Aristoflex® AVC 1% and 3% and propylene glycol 5% and 10%. The parameters were spreadability, adhesion, viscosity, and SPF values calculated in vitro using spectrophotometer. The results had been optimized by factorial design using Design Expert 7.1.5. Results: The combination of Aristoflex® AVC and propylene glycol had affected spreadability, adhesion, viscosity, and SPF value. The results had shown that the optimum formula of turmeric rhizome extract gel in the combination of Aristoflex® AVC and propylene glycol 1.68% and 9,87% respectively, so that the spreadability was 5.1 cm, adhesion was 2.018 seconds, viscosity was 110.008 dPas, and SPF value was 11.935. Conclusion: Combination of Aristoflex® AVC and propylene glycol affected on the spreadability, adhesion, viscosity, and SPF value of the turmeric rhizome extract gel. The proportion of Aristoflex® AVC 1.68% and propylene glycol 9.87% was the optimum formula. Keywords: aristoflex® AVC, gel, propylene glycol, turmeric, sunscreen