Aktivitas Gel Fraksi Etil Asetat dari Ekstrak Etanol Daun Ubi Jalar Untuk Pengobatan Luka Bakar

Abstract

Abstract Background: Burns are an event of loss of tissue caused by contact with a heat source. The use of natural ingredients as a burn treatment replaces drugs with synthetic materials that can have side effects. The natural ingredient that acted as a burn treatment is sweet potato leaves (Ipomoea batatas L.). Objective: This research focuses on using the ethyl acetate fraction from the ethanolic extract of sweet potato leaves as an alternative in the treatment of burns. Methods: The compounds in sweet potato leaves were extracted using 70% ethanol and fractionated using ethyl acetate as a solvent. Ethyl acetate fraction of sweet potato was identified to see secondary metabolites compounds. The ethyl acetate fraction of sweet potato leaves was formulated in a gel with a concentration of 1%, 2% and 3%. The burn test used a male Wistar strain test animal that had treated with second-degree burns. Burns were made using metal with a diameter of 2 cm heated on a bunsen fire. Burn observation was carried out every three days by measuring the diameter of the burn. Results: The statistical results showed p value > 0.05, indicating that there was no statistically significant difference. The qualitatively showed the difference in burn reduction, with the highest graph is obtained by using F2 at 2% concentration. Conclusion: The ethyl acetate fraction of sweet potato leaves provides activity in treatment of burns. Keywords: burns, fractions, gels, sweet potato leaves