Perbandingan Efikasi Karbamazepin, Gabapentin dan Amitriptilin terhadap Nyeri pada Penderita Polineuropati Diabetik

Abstract

ifferences in the mechanism of action of the drugs Carbamazepine, Gabapentin, and Amitriptyline can affect their effectiveness in reducing pain in diabetic polyneuropathy. To help select the most appropriate therapy to manage the pain, it is necessary to conduct this research. The research was conducted experimentally using a pretest-posttest group design. Pain response was measured using the Visual Analogue Scale (VAS) before and after treatment with Gabapentin, Carbamazepine, and Amitriptyline. Differences in pain response before and after treatment, as well as between treatments, were analyzed using the Mann-Whitney test and independent T-test. The results demonstrated that all three drugs were effective in reducing pain response in patients with diabetic polyneuropathy. However, Amitriptyline was found to be more effective in patients with mild to moderate pain compared to Gabapentin. These findings provide valuable information for healthcare providers in selecting the most effective treatment for patients with diabetic polyneuropathy pain.