Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/7218
Title: Treatment of The Cytokine Storm in COVID-19: Review of Clinical Pharmacology
Authors: Sapriati, Aisyah Nur
Rahmawati, Fita
Nuryastuti, Titik
Keywords: clinical pharmacology
COVID-19
coronavirus
cytokine storm
cytokine storm therapy
Issue Date: Aug-2023
Publisher: Jurnal Sains Farmasi & Klinis
Citation: Original Article
Abstract: The cause of the COVID-19 pandemic can be attributed to the Acute Respiratory Syndrome Virus-2 (SARS-CoV-2). COVID-19 manifests with severe symptoms in the upper respiratory tract and can progress to a critical condition due to an acute hyperinflammatory response that triggers a cytokine storm. The cytokine storm refers to an excessive or impaired production of proinflammatory cytokines, resulting in immune dysregulation and uncontrolled inflammatory activity. To effectively address the hyperinflammatory state induced by SARS-CoV-2 infection, it is imperative to explore promising strategies aimed at overcoming the cytokine storm, such as the prompt initiation of anti-inflammatory therapy. Several classes of drugs can potentially prevent the deterioration of COVID-19 patients by mitigating immune system dysregulation and suppressing uncontrolled inflammatory responses. These drug classes encompass corticosteroids, chloroquine and hydroxychloroquine, inhibitors of interleukin-1 (IL-1), inhibitors of interleukin-6 (IL-6), inhibitors of tumor necrosis factor (TNF), and anti-inflammatory drugs. Additionally, tumor necrosis factor alpha (TNF-α) inhibitors, as well as inhibitors targeting the Janus kinase signaling pathway and activator of transcription (JAK/STAT), have exhibited efficacy in treating COVID-19. This efficacy is evident when considering the drug's mechanism of action and pharmacokinetics, while also taking into account the tolerable side effects associated with their usage.
URI: http://localhost:8080/xmlui/handle/123456789/7218
Appears in Collections:VOL 10 NO 2 2023

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