Evaluasi Konversi Sputum dan Faktor Korelasinya pada Pasien Tuberkulosis Paru Kategori I dengan Diabetes Melitus

Abstract

Abstract Background: The prevalence of pulmonary TB increases in population of diabetes mellitus (DM). DM patients are higher risk for TB disease. It is suspected that in TB patients with DM, the failure rate of sputum conversion is greater than in TB without DM. Sputum conversion is an important indicator for evaluating the success of TB therapy. Objective: This study aims to evaluate the sputum conversion during 6 months of treatment with antituberculosis drugs as well as the factors that correlate to sputum conversion. Methods: This was a retrospective cohort study of category I pulmonary TB with DM with positive initial smear from 2017 to 2019. Data were collected from November 2019 to February 2020 in several health primary center in Surabaya. Results: There were 60 pulmonary TB with DM. There was a sputum conversion at the advanced phase of 96.6%. About 53% of patients fall into the normal BMI category and 37% of patients with a positive initial smear 1 (+1). Body mass index (BMI) and the positivity level of initial acid fast bacilli (AFB) were significant factors related to sputum by Kendal-Tau test (P = 0.000), while sex was not. Another result was success rate of 96.6% and a cure rate of 86.6%. Conclusion: The conclusion of this study is thatinTB patients with DM, there is no delay in sputum conversion during six months of treatment with first-line antituberculosis drugs with a percentage of sputum conversion of 96.6% at the end of the advanced phase. Keywords: pulmonary Tuberculosis, DM, sputum conversion, BMI, initial AFB