The Relationship of Drug Therapy Problems and Outcome Therapy in Tuberculosis Patients in Surabaya Health Center

Abstract

ABSTRACT Background:Tuberculosis (TB) is a highly contagious disease and is difficult to eradicate in Indonesia. Indonesia ranks second in the number of TB sufferers in the world. Generally, TB patients use more than two types of drug therapy, it can affect the drug therapy problems that arise and can affect the success of treatment.Objectives:This study aims to see the effect of the number of drugs used by TB patients on the number of drug therapy problems (DTP) and therapy outcomes in tuberculosis patients.Methods:This study was a cross-sectional study with purposive sampling conducted at health centers in the Surabaya area in January-June 2024. The sample inclusion criteria included pulmonary tuberculosis patients who had undergone treatment for over one month, were at least 17 years old, and could communicate well using a guided interview method.Results: The results showed that out of 110 patients, 30.0% used 4 types of drugs and 30.0% had two DTPs. Spearman's correlation test between the number of drugs and the number of DTPs with a p-value = 0.000 and a correlation coefficient of 0.472. Spearman's correlation test between the number of DTPs and therapy results with a p-value = 0.430 and a correlation coefficient of -0.076.Conclusion:From this study, it can be concluded that there is a significant relationship between the number of drugs and the number of DTPsin TB patients and there is no relationship between DTP and the results of therapy in TB patients.Therefore, pharmacists at health centers need to keep helping patients understand how to follow their TB treatment correctly, including the right dose, timing, intervals, and length of the treatment.Keywords: DTPs; Health centers; Outcome therapy; Tuberculosis