The Impact of Sub Acute Administration of Purified Gambier (Uncaria gambir Roxb.) to The Liver and Kidney Functions and its Reversibility on Rats

Abstract

Introduction: The impact of sub-acute administration of purified gambier (Uncaria gambir Roxb.) to the liver and kidney function and its reversibility had been studied on rats. Methods: Rats at the aged of 2-3 months and the bodyweight of ±250 g were treated with water solution of purified gambier at the dose of 5 mg/kg10 and 20 mg/kg for 7 to 14 consecutive days. Plasma ALP, AST activities, creatinine clearance, liver and kidney ratios were determined on the day 1, 7, 14 one week after the doses stopped. All data on each parameter were analyzed using two-way ANOVA followed by Duncan's multiple T-test and significance was taken at p<0.05. Results: The results showed that all parameters was not affected significantly (p>0.1), except ALT activity and liver organ ratio decreased significantly (p<0.05). Conclusion: These indicated that purified gambier is relatively non-toxic to the liver and the kidney of the rats at doses of 5-20 mg/kg BW for 14 days. Key Words: Purified gambier, Liver function, Renal function, ALP, ALT, CrCl.