Antidiabetic Regimen and Factors Associated with Glycemic Control in Patients with Type 2 Diabetes mellitus in Public Health Centers in Jakarta: A Cross-Sectional Study

Abstract

ABSTRACT The glycemic control of diabetes mellitus patients is affected by many factors, including its antidiabetic regimen. The purpose of this study was to describe the antidiabetic regimen used in patients with T2DM in the public health centers in Jakarta and to evaluate factors associated with glycemic control. A cross-sectional study was conducted in thirteen public health centers in Jakarta with HbA1C of ≤ 7% indicating good glycemic control and > 7% poor glycemic control. Factors that were potentially associated with glycemic control were performed univariate analysis test. Association between antidiabetic regimen and glycemic control were done by Pearson chi-square test and Fisher exact test. Sulfonylureas and biguanides as a combination were the most frequent (63.5%) prescribed in patients, while metformin was the most widely used antidiabetic of all prescriptions (49,43%). Univariate analysis showed that age, duration of T2DM, route of administration, number of antidiabetics, and number of other daily regular drugs significantly (P<0.05) related to glycemic control. Sulfonylurea and biguanide as monotherapy appeared associated with good glycemic control. However, further analysis is still needed to confirm whether it was affected by the antidiabetic regimens as other factors might be involved. Keywords: Type 2 Diabetes Mellitus; Antidiabetic regimen; Associated factors