Relationship between Dose and Retention of Methadon Maintenance Therapy to Drug Dependence Patients in Primary Health Care

Abstract

ABSTRACTMethadone Maintenance Therapy is one of the substitution therapies needed as a harm reduction approach to reduce the harm of drug abuse.This study aims to determine the relationship between dose and retention in drug-dependent patients on the methadone maintenance therapy (MMT) program at Kramat JatiDistrict Health Center in 2009-2018. This type of research is cross-sectional using secondary data from medical records which are then analyzed for their meaning. This study involved 136 patients who met the inclusion criteria. The results of statistical analysis showed that the average initial dose received by patients was 27.65 mg (range 10-40 mg), and after 2 weeks of therapy, the average dose received by patients was 51.6 mg (range 22.5-85 mg). The mean of the smallest and largest maintenance doses received by patients was30.9mg (range 0.25-115 mg) and 84.39 mg (range 15-140 mg), meanwhilethe average maintenance dose received by patients was 62.36. mg (range 7.77-126.92 mg). This study shows that the retention value of 1 year or more reaches 64.71%.The 2-week maintenance dose (P=0.005), the smallest maintenance dose (P=0.000), the mean maintenance dose (P=0.004), and a history of missed doses (P=0.000) were significantly associated with retention. From the results of this study, it can be concluded that the more optimal the maintenance dose received by the patient, the greater the patient's retention in undergoing methadone maintenance therapy, conversely, the smaller the frequency of missed doses, the better the patient's retention in undergoing methadone maintenance therapy.Keywords:Methadone Dosage;Retention;Methadone Maintenance Therapy