Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/6811
Title: A seven-year surveillance of Candida bloodstream infection at a university hospital in KSA
Authors: Al-Musawi, Tariq S.
Alkhalifa, Wala A.
Alasaker, Norah A.
Rahman, Jawad U.
Alnimr, Amani M.
Keywords: Antifungal susceptibility testing
Candidemia
Epidemiological shift
Mortality
Non albicans
Issue Date: 2021
Publisher: Journal of Taibah University Medical Sciences
Series/Report no.: Original Article;184-190
Abstract: Objectives: Candidemia incidence has increased in the past few years, with high mortality. Previous studies have reported a variable distribution of Candida spp. among different regions. This study aimed to identify the species found in Candida bloodstream infections, routine antifungal susceptibility testing, and mortality outcomes in an academic medical centre. Methods: Between January 2012 and December 2018, the positive blood cultures for candidemia infection were retrieved and statistically analysed for species prevalence, susceptibility pattern, and crude mortality at 14, 30, 60 and 90 days. Results: Of 156 candidemia cases, a majority (69.2%) was caused by non-albicans Candida spp. After Candida albicans (30.8%), Candida tropicalis and Candida parapsilosis were the second and third most frequeunt isolates spp, each counting for 23.7%. Acquired resistance was detected in 14.8% of candidemia strains. No other antifungal resistance was detected. The overall crude mortality rates of all species were 29.3%, 47.9%, 56.4%, and 58.0% at 14, 30, 60, and 90 days, respectively. A higher mortality rate was noted in cases of Candida krusei infection (crude mortality 71.4e100%, p ¼ 0.002). Conclusion: In this study, a considerable shift to nonalbicans Candida causing most bloodstream infections was observed. As such infections pose a serious threat to hospitalised patients, microbiology laboratories are urged to adopt rapid diagnostic and minimal inhibitory concentration-based testing for the detection of susceptible dose-dependent phenotypes. Prospective studies are essential to consider the prognosis of bloodstream infections by various Candida species in a multivariate model.
URI: http://localhost:8080/xmlui/handle/123456789/6811
ISSN: 1658-3612
Appears in Collections:Vol 16 No 2 (2021)

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