Pola Resistansi Antibiotik Bakteri Penyebab Infeksi Saluran Kemih di Puskesmas Ibrahim Adjie Kota Bandung

Abstract

The bacteria that cause urinary tract infections (UTIs) have developed resistance to various antibiotics. Data about the pattern of bacterial resistance need to be updated to ensure proper antibiotic administration. The research aimed to identify and perform the pattern of bacterial resistance from UTI patients at the Ibrahim Adjie Health Center, Bandung City. The urine samples of 9 suspected UTI patients were determined for the number of bacterial colonies. It turned out 3 samples whose number of bacterial colonies fulfil the UTI criteria i.e above 10 5 cfu/ml. The isolates were subsequently determined for Gram bacteria, isolation of bacterial chromosome DNA, amplification of 16S rRNA gene, DNA sequencing, and antibiotic resistance tests against penicillin, penicillin + β-lactamase inhibitor, cephalosporin (generation 1,2,3,4), fluoroquinolone, aminoglycoside and carbapenem. Three isolates (P1, P2, P3) were genetically identified as Escherichia coli. P1 was resistant to penicillin, penicillin + β-lactamse inhibitor, cephalosporin generation 1 and fluoroquinolone. P2 was just resistant to penicillin. P3 was resistant to penicillin, penicillin + β-lactamse inhibitor, cephalosporin (generation 1,2,3,4) and fluoroquinolone. These E. coli had developed resistance to penicillin, penicillin + β-lactamase inhibitor, cephalosporin (generation 1,2,3,4) and fluoroquinolone. Aminoglycoside and carbapenem still have activity against these E. coli.