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dc.contributor.authorKe, Yamin-
dc.contributor.authorHu, Huifang-
dc.contributor.authorZhang, Jinli-
dc.contributor.authorYuan, Lijun-
dc.contributor.authorZhang, Ming-
dc.contributor.authorWang, Longkang-
dc.date.accessioned2024-09-24T03:16:07Z-
dc.date.available2024-09-24T03:16:07Z-
dc.date.issued2023-03-24-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/6229-
dc.description.abstractABSTRACT Alcohol consumption remains inconsistently correlated with fracture risk, and a dose–response meta-analysis for specific outcomes is lacking. The objective of this study was to quantitatively integrate the data on the relationship between alcohol consumption and fracture risk. Pertinent articles were identified in PubMed, Web of Science, and Embase databases up to 20 February 2022. Combined RRs and 95% CIs were estimated by random- or fixed-effects models. Restricted cubic splines were used to model linear or nonlinear relationships. Fortyfour articles covering 6,069,770 participants and 205,284 cases of fracture were included. The combined RRs and 95% CIs for highest compared with lowest alcohol consumption were 1.26 (1.17–1.37), 1.24 (1.13–1.35), and 1.20 (1.03–1.40) for total, osteoporotic, and hip fractures, respectively. A linear positive relationship between alcohol consumption and total fracture risk was detected (Pnonlinearity ¼ 0.057); the risk was correlated with a 6% increase (RR, 1.06; 95% CI: 1.02, 1.10) per 14 g/d increment of alcohol consumption. J-shaped relationships of alcohol consumption with risk of osteoporotic fractures (Pnonlinearity < 0.001) and hip fractures (Pnonlinearity < 0.001) were found. Alcohol consumption of 0 to 22 g/d was linked to a reduced risk of osteoporotic fractures and hip fractures. Our findings show that any level of alcohol consumption is a risk factor for total fractures. Moreover, this dose–response meta-analysis shows that an alcohol consumption level of 0 to 22 g/d is related to a reduction in the risk of osteoporotic and hip fractures. The protocol was registered in the International Prospective Register of Systematic Reviews (CRD42022320623). Keywords: alcohol intake, fracture, dose–response, prospective cohort study, meta-analysisen_US
dc.language.isoenen_US
dc.publisherAdvances in Nutritionen_US
dc.subjectalcohol intake,en_US
dc.subjectfracture,en_US
dc.subjectdose–response,en_US
dc.subjectprospective cohort study,en_US
dc.subjectmeta-analysisen_US
dc.titleAlcohol Consumption and Risk of Fractures: A Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studiesen_US
dc.typeArticleen_US
Appears in Collections:VOL 14 No 4 2023

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