Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5942
Title: Roles of Diet-Associated Gut Microbial Metabolites on Brain Health: Cell-to-Cell Interactions between Gut Bacteria and the Central Nervous System
Authors: Kim, Chong-Su
Keywords: dietary metabolites
gut microbiota
gut–brain axis
astrocytes
microglia
neurons
cell-to-cell interaction
mental health
Issue Date: 2024
Publisher: Advances in Nutrition
Series/Report no.: Review;100136
Abstract: Gut microbiota have crucial effects on brain function via the gut–brain axis. Growing evidence suggests that this interaction is mediated by signaling molecules derived from dietary components metabolized by the intestinal microbiota. Although recent studies have provided a substantial understanding of the cell-specific effects of gut microbial molecules in gut microbiome–brain research, further validation is needed. This review presents recent findings on gut microbiota-derived dietary metabolites that enter the systemic circulation and influence the cell-to-cell interactions between gut microbes and cells in the central nervous system (CNS), particularly microglia, astrocytes, and neuronal cells, ultimately affecting cognitive function, mood, and behavior. Specifically, this review highlights the roles of metabolites produced by the gut microbiota via dietary component transformation, including short-chain fatty acids, tryptophan metabolites, and bile acid metabolites, in promoting the function and maturation of brain cells and suppressing inflammatory signals in the CNS. We also discuss future directions for gut microbiome–brain research, focusing on diet-induced microbial metabolite-based therapies as possible novel approaches to mental health treatment.
URI: http://localhost:8080/xmlui/handle/123456789/5942
Appears in Collections:VOL 15 NO 1 (2024)

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