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Title: | Roles of Diet-Associated Gut Microbial Metabolites on Brain Health: Cell-to-Cell Interactions between Gut Bacteria and the Central Nervous System |
Authors: | Kim, Chong-Su |
Keywords: | dietary metabolites gut microbiota gut–brain axis astrocytes microglia neurons cell-to-cell interaction mental health |
Issue Date: | 2024 |
Publisher: | Advances in Nutrition |
Series/Report no.: | Review;100136 |
Abstract: | Gut microbiota have crucial effects on brain function via the gut–brain axis. Growing evidence suggests that this interaction is mediated by signaling molecules derived from dietary components metabolized by the intestinal microbiota. Although recent studies have provided a substantial understanding of the cell-specific effects of gut microbial molecules in gut microbiome–brain research, further validation is needed. This review presents recent findings on gut microbiota-derived dietary metabolites that enter the systemic circulation and influence the cell-to-cell interactions between gut microbes and cells in the central nervous system (CNS), particularly microglia, astrocytes, and neuronal cells, ultimately affecting cognitive function, mood, and behavior. Specifically, this review highlights the roles of metabolites produced by the gut microbiota via dietary component transformation, including short-chain fatty acids, tryptophan metabolites, and bile acid metabolites, in promoting the function and maturation of brain cells and suppressing inflammatory signals in the CNS. We also discuss future directions for gut microbiome–brain research, focusing on diet-induced microbial metabolite-based therapies as possible novel approaches to mental health treatment. |
URI: | http://localhost:8080/xmlui/handle/123456789/5942 |
Appears in Collections: | VOL 15 NO 1 (2024) |
Files in This Item:
File | Description | Size | Format | |
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22. Roles-of-Diet-Associated-Gut-Microbial-Metabolites-Review.pdf | 100136 | 596.95 kB | Adobe PDF | View/Open |
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