Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5662
Title: Effect of Alpha-Linolenic Acid Supplementation on Cardiovascular Disease Risk Profile in Individuals with Obesity or Overweight: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Yin, Shiyu
Xu, Hai
Xia, Jiayue, dkk
Keywords: alpha-linolenic acid
cardiovascular disease risk
overweight
obesity
inflammation
blood pressure
blood lipid
Issue Date: 29-Sep-2023
Publisher: Advances in Nutrition
Series/Report no.: 1644-1655;
Abstract: Overweight and obesity are highly prevalent worldwide and are associated with cardiovascular disease (CVD) risk factors, including systematic inflammation, dyslipidemia, and hypertension. Alpha-linolenic acid (ALA) is a plant-based essential polyunsaturated fatty acid associated with reduced CVD risks. This systematic review and meta-analysis aimed to investigate the effects of supplementation with ALA compared with the placebo on CVD risk factors in people with obesity or overweight (International Prospective Register of Systematic Reviews Registration No. CRD42023429563). This review included studies with adults using oral supplementation or food or combined interventions containing vegetable sources of ALA. All studies were randomly assigned trials with parallel or crossover designs. The Cochrane Collaboration tool was used for assessing the risk of bias (Version 1). PubMed, Web of Science, Embase, and Cochrane library databases were searched from inception to April 2023. Nineteen eligible randomized controlled trials, including 1183 participants, were included in the meta-analysis. Compared with placebo, dietary ALA supplementation significantly reduced C-reactive protein concentration (standardized mean difference [SMD] ¼ –0.38 mg/L; 95% confidence interval [CI]: –0.72, –0.04), tumor necrosis factor-α concentration (SMD ¼ –0.45 pg/mL; 95% CI: –0.73, –0.17), triglyceride in serum (SMD¼ 4.41 mg/dL; 95% CI: –5.99, –2.82), and systolic blood pressure (SMD ¼ –0.37 mm Hg; 95% CI: –0.66, –0.08); but led to a significant increase in low-density lipoprotein cholesterol concentrations (SMD ¼ 1.32 mg/dL; 95% CI: 0.05, 2.59). ALA supplementation had no significant effect on interleukin-6, diastolic blood pressure, total cholesterol, or high-density lipoprotein cholesterol (all P 0.05). Subgroup analysis revealed that ALA supplementation at a dose of 3 g/d from flaxseed and flaxseed oil had a more prominent effect on improving CVD risk profiles, particularly where the intervention duration was 12 wk and where the baseline CVD profile was poor.
URI: http://localhost:8080/xmlui/handle/123456789/5662
Appears in Collections:VOL 14 NO 6 (2023)

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