Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5248
Title: Physiological Roles of Carnosine in Myocardial Function and Health
Authors: V Creighton, Jade
Souza Gonçalves, Lívia de
G Artioli, Guilherme
Tan, Di
J Elliott-Sale, Kirsty
Turner, D
L Doig, Craig
Sale, Craig
Keywords: animals
, β-alanine
, carnosine
, calcium transients,
, heart
, humans
, lipid peroxidation,
oxidative stress
Issue Date: 2022
Publisher: Oxford University Press on behalf of the American Society for Nutrition 2022
Abstract: Carnosine is a pleiotropic histidine-containing dipeptide synthesized from β-alanine and L-histidine, with the intact dipeptide and constituent amino acids being available from the diet. The therapeutic application of carnosine in myocardial tissue is promising, with carnosine playing a potentially beneficial role in both healthy and diseased myocardial models. This narrative review discusses the role of carnosine in myocardial function and health, including an overview of the metabolic pathway of carnosine in the myocardial tissue, the roles carnosine may play in the myocardium, and a critical analysis of the literature, focusing on the effect of exogenous carnosine and its precursors on myocardial function. By so doing, we aim to identify current gaps in the literature, thereby identifying considerations for future research
URI: http://localhost:8080/xmlui/handle/123456789/5248
Appears in Collections:VOL 13 NO 5 2022

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