Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/5241
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dc.contributor.authorWang, Guoyan-
dc.contributor.authorChen, Lei-
dc.contributor.authorQin, Senlin-
dc.contributor.authorZhang, Tingting-
dc.contributor.authorYao, Junhu-
dc.contributor.authorYi, Yanglei-
dc.contributor.authorDeng, Lu-
dc.date.accessioned2023-08-02T07:22:14Z-
dc.date.available2023-08-02T07:22:14Z-
dc.date.issued2022-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/5241-
dc.description.abstractMechanistic target of rapamycin complex 1 (mTORC1) is a multi-protein complex widely found in eukaryotes. It serves as a central signaling node to coordinate cell growth and metabolism by sensing diverse extracellular and intracellular inputs, including amino acid–, growth factor–, glucose-, and nucleotide-related signals. It is well documented that mTORC1 is recruited to the lysosomal surface, where it is activated and, accordingly, modulates downstream effectors involved in regulating protein, lipid, and glucose metabolism. mTORC1 is thus the central node for coordinating the storage and mobilization of nutrients and energy across various tissues. However, emerging evidence indicated that the overactivation of mTORC1 induced by nutritional disorders leads to the occurrence of a variety of metabolic diseases, including obesity and type 2 diabetes, as well as cancer, neurodegenerative disorders, and aging. That the mTORC1 pathway plays a crucial role in regulating the occurrence of metabolic diseases renders it a prime target for the development of effective therapeutic strategies. Here, we focus on recent advances in our understanding of the regulatory mechanisms underlying how mTORC1 integrates metabolic inputs as well as the role of mTORC1 in the regulation of nutritional and metabolic diseasesen_US
dc.language.isoenen_US
dc.publisherOxford University Press on behalf of the American Society for Nutrition 2022en_US
dc.subjectmTORC1,en_US
dc.subjectnutrient,en_US
dc.subjectsignal transduction,en_US
dc.subjectmetabolism,en_US
dc.subjectmetabolic diseasesen_US
dc.titleMechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and Healthen_US
dc.typeArticleen_US
Appears in Collections:VOL 13 NO 5 2022

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