Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance

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DC Field	Value	Language
dc.contributor.author	Kim, Yujeong	-
dc.contributor.author	Kim, Ok-Kyung	-
dc.date.accessioned	2023-06-13T07:23:45Z	-
dc.date.available	2023-06-13T07:23:45Z	-
dc.date.issued	2021	-
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/4877	-
dc.description.abstract	Recently, extracellular microRNAs (miRNAs) from adipose tissue have been shown to be involved in the development of insulin resistance. Here, we summarize several mechanisms explaining the pathogenesis of obesity-induced insulin resistance and associated changes in the expression of obesity-associated extracellular miRNAs. We discuss how miRNAs, particularly miR-27a, miR-34a, miR-141-3p, miR-155, miR210, and miR-222, in extracellular vesicles secreted from the adipose tissue can affect the insulin signaling pathway in metabolic tissue. Understanding the role of these miRNAs will further support the development of therapeutics for obesity and metabolic disorders such as type 2 diabetes	en_US
dc.language.iso	en_US	en_US
dc.publisher	Advances in Nutrition	en_US
dc.relation.ispartofseries	Review;566-574	-
dc.subject	extracellular vesicle	en_US
dc.subject	miRNAs	en_US
dc.subject	obesity	en_US
dc.subject	insulin resistance	en_US
dc.subject	insulin signaling	en_US
dc.title	Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance	en_US
dc.type	Article	en_US
Appears in Collections:	VOL 12 NO 2 (2021)

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