Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/4859
Title: Tea Drinking and Risk of Cancer Incidence: AMeta-Analysis of Prospective Cohort Studies and Evidence Evaluation
Authors: Zhao, Long-Gang
Li, Zhuo-Ying
Feng, Guo-Shan
Ji, Xiao-Wei
Tan, Yu-Ting
Li, Hong-Lan
Gunter, Marc J
Xiang, Yong-Bing
Keywords: tea
cancer
meta-analysis
grading evidence
prospective studies
Issue Date: 2021
Publisher: Advances in Nutrition
Series/Report no.: Review;402-412
Abstract: Here we provide a comprehensive meta-analysis to summarize and appraise the quality of the current evidence on the associations of tea drinking in relation to cancer risk. PubMed, Embase, and the Cochrane Database of Systematic Reviews were searched up to June 2020. We reanalyzed the individual prospective studies focused on associations between tea drinking and cancer risk in humans. We conducted a metaanalysis of prospective studies and provided the highest- versus lowest-category analyses, dose-response analyses, and test of nonlinearity of each association by modeling restricted cubic spline regression for each type of tea. We graded the evidence based on the summary effect size, its 95% confidence interval, 95% prediction interval, the extent of heterogeneity, evidence of small-study effects, and excess significance bias.We identified 113 individual studies investigating the associations between tea drinking and 26 cancer sites including 153,598 cancer cases. We assessed 12 associations for the intake of black tea with cancer risk and 26 associations each for the intake of green tea and total tea with cancer risk. Except for an association between lymphoid neoplasms with green tea, we did not find consistent associations for the highest versus lowest categories and dose-response analyses for any cancer. When grading current evidence for each association (number of studies ≥2), weak evidence was detected for lymphoid neoplasm (green tea), glioma (total tea, per 1 cup), bladder cancer (total tea, per 1 cup), and gastric and esophageal cancer (tea, per 1 cup). This review of prospective studies provides little evidence to support the hypothesis that tea drinking is associated with cancer risk. More well-designed studies are still needed to identify associations between tea intake and rare cancers.
URI: http://localhost:8080/xmlui/handle/123456789/4859
Appears in Collections:VOL 12 NO 2 (2021)

Files in This Item:
File Description SizeFormat 
402-412.pdf969.51 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.