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dc.contributor.authorJianmin Wu-
dc.contributor.authorNing Ma-
dc.contributor.authorJohnston, Lee J-
dc.contributor.authorXi Ma-
dc.date.accessioned2023-06-07T07:20:52Z-
dc.date.available2023-06-07T07:20:52Z-
dc.date.issued2020-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/4774-
dc.description.abstractThe intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient digestion and absorption, and microbial survival. The gut in animals faces continuous challenges in communicating with the external environment. Threats from endogenous imbalance and exogenous feeds, especially pathogens, could trigger a disorder of homeostasis, leading to intestinal disease and even systematic disease risk. As a part of the intestinal protective barrier, endogenous host defense peptides (HDPs) play multiple beneficial physiological roles in the gut mucosa. Moreover, enhancing endogenous HDPs is being developed as a new strategy for resisting pathogens and commensal microbes, and to maintain intestinal health and reduce antibiotic use. In recent years, multiple nutrients such as branched-chain amino acids, SCFAs, lactose, zinc, and cholecalciferol (vitamin D3) have been reported to significantly increase HDP expression. Nutritional intervention has received more attention and is viewed as a promising means to defend against pathogenic infections and intestinal inflammation. The present review focuses on current discoveries surrounding HDP expression and nutritional regulation of mechanisms in the gut. Our aim is to provide a comprehensive overview, referable tactics, and novel opinionsen_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Nutritionen_US
dc.subjectnutrientsen_US
dc.subjectpathogensen_US
dc.subjectinflammationen_US
dc.subjecthost defense peptidesen_US
dc.subjectantibiotic alternativeen_US
dc.titleDietary Nutrients Mediate Intestinal Host Defense Peptide Expressionen_US
dc.title.alternativeAdvances in Nutritionen_US
dc.typeArticleen_US
Appears in Collections:VOL 11 NO 1 (2020)

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