Association between sociodemographic factors and estrogen Association progesterone receptor-positive breast cancer receptor-positive, progesterone receptor-positive breast cancer subtypes: A cross-sectional study

Abstract

Association between sociodemographic factors and estrogen receptor-positive, progesterone receptor-positive breast cancer subtypes: A cross-sectional study

Vinodkumar Mugada * , Raj Kiran Kolakota, Varsha Mahato

Department of Pharmacy Practice, Vignan Institute of Pharmaceutical Technology, Visakhaptnam 530049, India

*E-mail: mugadavinodkumar18@gmail.com

Abstract

Background: The presence of risk factors have a high risk of developing breast cancer. Our study aimed to find an association between sociodemographic factors and the risk of estrogen receptor (ER)-positive, progesterone receptor (PR)positive breast cancer among women. Methods: A cross-sectional study was conducted on 200 women with breast cancer.

Association between sociodemographic factors and hormone receptor subtypes of breast cancer was found using the Chisquare

test. Multiple logistic regression analysis was used to know the strong predictors of hormone receptor subtypes. Results: The mean age was 50.08 (10.67) years. Comorbidities had a statistically significant association with ER-positive subtype (p = 0.007). Body mass index had a statistically significant association with PR-positive subtype (p = 0.042). Comorbidities was found to be the strong independent predictor for ER-positive (OR 2.28; 95% CI: 1.28–4.05, p = 0.01) and PR-positive subtypes (OR 1.78; 95% CI: 1.01–3.13, p = 0.03). Conclusion: We conclude that in our study, body mass index was associated with PR-positive subtype, and comorbidities were associated with ER-positive subtype of breast cancer among the women. Comorbidities remained to be a strong independent predictor of ER-positive and PRpositive subtypes of breast cancer.

Keywords: body mass index, breast cancer, comorbidities, estrogen receptor, progesterone receptor