Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/2820
Title: A Safety Study of Local Injection of Two Concentrations of Pituitrin in Laparoscopic Uterine Fibroid Surgery: A Randomized Clinical Trial
Authors: Cao, Xia
Ma, Jun
Keywords: bleeding
hemodynamics\
laparoscopy
uterine fibroid
pituitrin
surgery
Issue Date: Apr-2022
Abstract: A Safety Study of Local Injection of Two Concentrations of Pituitrin in Laparoscopic Uterine Fibroid Surgery: A Randomized Clinical Trial Xia Cao1,2 , Jun Ma1,* 1Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China 2Department of Anesthesiology, Fuxing Hospital, Capital Medical University, 100038 Beijing, China *Correspondence: majun@mail.ccmu.edu.cn (Jun Ma) Academic Editor: Andrea Tinelli Submitted: 23 January 2022 Revised: 13 February 2022 Accepted: 17 February 2022 Published: 5 May 2022 Abstract Background: The purpose of the study was to compare the safety of local injection of 6 units of pituitrin diluted to 20 mL vs 6 units of pituitrin diluted to 10 mL for laparoscopic uterine fibroid (UF) surgery. Methods: This was a randomized clinical trial of patients scheduled for laparoscopic UF surgery at Fu Xing Hospital, Capital Medical University, Beijing, China. Ninety-six patients were divided into two groups according to the concentration of pituitrin utilized: Group1 (6 units of pituitrin diluted to 20 mL for all injection) 48 cases; Group2 (6 units of pituitrin diluted to 10 mL for all injection) 48 cases. The observation indicators were mean arterial pressure (MAP1) and heart rate (HR1) upon entering the operating room; the lowest mean arterial pressure (MAP2) and the highest heart rate (HR2) within 5 minutes after injecting pituitrin; the highest mean arterial pressure (MAP3) and the lowest heart rate (HR3) within 30 minutes after injecting pituitrin; hemoglobin (Hb1) and hematocrit (Hct1) within one week before surgery; hemoglobin (Hb2) and hematocrit (Hct2) within one day after surgery; and the time for the mean arterial pressure to return to the level of entering the operation room after using pituitrin (Recovery Time). Results: All baseline and observation data showed no statistical difference between the two groups. Conclusions: The safety profile of local injection of pituitrin in the 6 units of pituitrin diluted to 20 mL and 6 units of pituitrin diluted to 10 mL are the same when used for laparoscopic UF surgery. Keywords: bleeding; hemodynamics; laparoscopy; uterine fibroid; pituitrin; surgery
URI: http://localhost:8080/xmlui/handle/123456789/2820
Appears in Collections:2. Clinical and Experimental Obstetrics & Gynecology

Files in This Item:
File Description SizeFormat 
2709-0094-49-5-103.pdf515.93 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.