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dc.contributor.authorKarakus, Cemil-
dc.contributor.authorTurktekin, Nurettin-
dc.contributor.authorOzyurt, Ramazan-
dc.date.accessioned2022-08-11T14:43:27Z-
dc.date.available2022-08-11T14:43:27Z-
dc.date.issued2022-03-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/2795-
dc.description.abstractRegulation of endometrial NF-κB expression in patients with PCOS undergoing total embryo freezing Cemil Karakus1,*, Nurettin Turktekin2 , Ramazan Ozyurt3 1Vocational School of Health Services, Beykent University, 34398 Istanbul, Turkey 2Vocational School of Health Services, Nişantaşı University, 34398 Istanbul, Turkey 3 Istanbul IVF-Center, 34398 Istanbul, Turkey *Correspondence: drckarakus@gmail.com (Cemil Karakus) Academic Editor: Michael H. Dahan Submitted: 22 May 2021 Revised: 16 August 2021 Accepted: 24 August 2021 Published: 30 March 2022 Abstract Background: To investigate Nuclear Factor kappa B (NF-κB) expression pattern in the endometrial samples taken on the day of egg collection in women with polycystic ovarian syndrome (PCOS)scheduled for total embryo freezing due to the risk of ovarian hyperstimulation syndrome (OHSS). Methods: Forty women with PCOS scheduled for total embryo freezing due to the risk of ovarian hyperstimulation syndrome were included in the study. Twenty-five infertile women who decided to freeze all of their embryos for any reason other than PCOS were utilized as the control group. Endometrial sampling was performed from all patients in both groups immediately following the egg collection. Five fertile women with at least two children constituted the second control group. Endometrial sampling was performed from fertile patients during the mid-luteal phase. After immunohistochemical staining of endometrial samples with NF-κB/p65, the intensity of endometrial NF-κB/p65 expression was measured utilizing the H-score method. Results: NF-κB/p65 immunoreactivity was detected in both luminal and glandular endometrial cells from all samples. The mean H-score of endometrial NFκB/p65 expression in the PCOS group was significantly increased compared to age and Body mass index (BMI) matched control group and fertile controls. NF-κB/p65 immunoreactivity of the control and fertile groups were found to be similar. There was no statistically significant difference in the mean H-score of endometrial NF-κB/p65 expression between the control and fertile groups. A positive and significant correlation was found between H-score values of NF-κB and E2 (estradiol), endometrial thickness, total oocyte count and total follicle stimulating hormone (rFSH) dose on human chorionic gonadotropin (hCG) day. Similarly, a strong positive correlation was found between serum testosterone, insulin levels, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) values and NF-κB values. In addition to progesterone values on hCG day, no significant correlation was found between other parameters and NF-κB. Conclusions: Increased endometrial NF-κB/p65 expression may contribute to the diminished reproductive potential of women with PCOS undergoing total embryo freezing. Keywords: PCOS; NF-κB/p65; Total embryo freezing; Endometrium; OHSSen_US
dc.subjectPCOSen_US
dc.subjectNF-κB/p65en_US
dc.subjectTotal embryo freezingen_US
dc.subjectEndometriumen_US
dc.subjectOHSSen_US
dc.titleRegulation of endometrial NF-κB expression in patients with PCOS undergoing total embryo freezingen_US
dc.typeArticleen_US
Appears in Collections:2. Clinical and Experimental Obstetrics & Gynecology

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