Pregnancy outcomes in women with moderate and severe aortic stenosis

Abstract

Pregnancy outcomes in women with moderate and severe aortic stenosis Dong Yang1 , Hao-Feng Zhang1 , Zhao-Liang Bao1 , He Zhao1 , Yan-Na Li1 , Jun Zhang1,* 1Department of Obstetrics and Gynecology, Beijing Anzhen Hospital affiliated to Capital Medical University, 100011 Beijing, China *Correspondence: a22121332@163.com (Jun Zhang) Academic Editor: Michael H. Dahan Submitted: 31 August 2020 Revised: 4 November 2020 Accepted: 28 November 2020 Published: 6 January 2022 Abstract Background: Aortic stenosis (AS) is one of the degenerative heart lesions mainly resulting from congenital defects and rheumatic diseases. This study aimed to determine maternal and fetal outcomes in pregnant women with moderate and severe AS. Methods: The clinical data of 26 pregnant women with AS treated between 2007 and 2019 in Beijing Anzhen Hospital were collected and retrospectively analyzed. Results: AS was diagnosed before pregnancy or after pregnancy in 16 (61.5%) and 10 (38.5%) patients, respectively. Except the peak velocity and mean pressure gradient, no significant difference in baseline cardiac parameters between the patients with moderate AS and severe/very severe AS, such as AS locations, previous heart failure symptoms, and heart function was seen. Heart failure and arrhythmia were complicated in 14 (53.8%) and 6 (23.1%) pregnancies, respectively. The rate of Caesarean deliveries was 85.7% in the patients with severe/very severe AS and 58.3% in the patients with moderate AS. There was no neonatal asphyxia or neonatal death in the cohort. Conclusions: The results of our study indicate the pre-conceptional evaluation and counseling should be performed in women with AS and those with symptomatic and severe AS are recommend to take cardiac surgery as appropriate before pregnancy. Keywords: Aortic stenosis; Pregnancy; Mortality; Pregnancy outcome