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dc.contributor.authorLiang, Lin-
dc.contributor.authorZhao, Xiao Xi-
dc.date.accessioned2022-08-11T03:56:11Z-
dc.date.available2022-08-11T03:56:11Z-
dc.date.issued2021-10-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/2713-
dc.description.abstractThe effect of follicular fluid-related hormones and vascular endothelial factor levels on the formation of high-quality embryos Lin Liang1 , Xiao Xi Zhao2, * 1 The Reproductive Center, Affiliate Hospital of Inner Mongolia Medical University, 010050 Hohhot, Inner Mongolia, China 2Department of Gynecology and Obstetrics, Affiliate Hospital of Inner Mongolia Medical University, 010050 Hohhot, Inner Mongolia, China *Correspondence: zhaoxx.3675@163.com (Xiao Xi Zhao) DOI:10.31083/j.ceog4805178 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: 1 January 2021 Revised: 11 February 2021 Accepted: 23 March 2021 Published: 15 October 2021 Background: The purpose of this study was to investigate the possible influence of follicular fluid (FF)-related hormones and vascular endothelial factor (VEGF) levels on oocytes, and the resulting effect on formation of high-quality embryos, to provide a scientific basis for improving controlled ovarian stimulation. Methods: The levels of hormones and VEGF in FF were determined by performing enzymelinked immunoassays. According to the number of high-quality embryos obtained, the patients were divided into three groups, and the levels and constitution of hormones and VEGF in FF were compared. Based on the results of correlation analysis, the number of oocytes harvested and the concentration of follicle-stimulating hormone (FSH) in FF were substituted into multiple logistic regression models. Results: The number of high-quality embryos was negatively correlated with FSH concentration (correlation coefficient = −0.305, p = 0.0001). The concentration of VEGF, FSH, luteinising hormone, and estradiol in FF was significantly different among the different high-quality embryo number groups. Multiple logistic regression results showed that the FSH concentration in the FF of the group without embryos was significantly higher than that of the other two groups, and the number of eggs obtained in the third group was significantly higher than that of the group without embryos. Conclusion: In the late stage of follicular development, FSH concentration in FF and the number of oocytes obtained affects the formation of highquality embryos. Keywords Follicular fluid; Vascular endothelial growth factor; Hormonesen_US
dc.subjectFollicular fluiden_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectHormonesen_US
dc.titleThe effect of follicular fluid-related hormones and vascular endothelial factor levels on the formation of high-quality embryosen_US
dc.typeArticleen_US
Appears in Collections:2. Clinical and Experimental Obstetrics & Gynecology

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