Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy?

Abstract

Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? Ozgur Sahin1 , H. Egemen Tolunay2 , Tufan Arslanca3, * , S. Banu Arslanca2 1Department of Obstetrics and Gynecology, Canakkale State Hospital, 17010 Canakkale, Turkey 2Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Maternity and Women's Health Teaching and Research Hospital, 06070 Ankara, Turkey 3Department of Obstetrics and Gynecology, Ufuk University, 06510 Ankara, Turkey *Correspondence: drtufanarslanca@hotmail.com (Tufan Arslanca) DOI:10.31083/j.ceog4805172 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: 11 December 2020 Revised: 28 January 2021 Accepted: 14 February 2021 Published: 15 October 2021 Background: Polyhydramnios is a common cause of adverse pregnancy outcomes. The prediction of polyhydramnios in early pregnancy may lead to improved treatments and will diminish these adverse outcomes. Objective: This study aims to investigate the role of biochemical markers in antenatal screening tests to predict idiopathic polyhydramnios. Methods: Patient records were retrospectively evaluated in this case-control group study. Pregnant women (160 in total) were included in the study (this included 47 pregnant women diagnosed with idiopathic polyhydramnios and 113 healthy pregnant women as a control group). Results: Alphafetoprotein, unconjugated estriol, and total beta-human chorionic gonadotropin values were similar in both groups (p = 0.296, p = 0.573, p = 0.284). There was no significant difference between the group diagnosed with idiopathic polyhydramnios and the control group when the first-trimester screening test parameter, pregnancyassociated plasma protein-A, was examined (p = 0.102). Conclusion: Biochemical markers examined in prenatal screening tests in the first and second trimesters were insufficient to predict idiopathic Polyhydramnios. The reasons for this are that our study was retrospective, and the patient population was low. We believe that a prospective study with a larger population of patients should be conducted for more meaningful results. Keywords Antenatal screening; Biochemical markers; Polyhydramnios