Role of Lifestyle Modifi cation through Dietary Changes to Endometrial Receptivity on Infertility Women and Obesity with Polycystic Ovary Syndrome

Abstract

Role of Lifestyle Modifi cation through Dietary Changes to Endometrial Receptivity on Infertility Women and Obesity with Polycystic Ovary Syndrome Peran Perubahan Gaya Hidup melalui Perubahan Pola Diet terhadap Reseptivitas Endometrium Perempuan Infertil dan Obesitas dengan Sindrom Ovarium Polikistik Julianto Witjaksono 1 , Fiastuti Witjaksono 2 , Andhika A. Perdana 1 1 Department of Obstetrics and Gynecology 2 Department of Clinical Nutrition Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Indonesia Jakarta Abstract Abstrak Objective: To investigate the effect of lifestyle modifi cation on endometrial receptivity of obese women with polycystic ovary syndrome using ultrasonography. Tujuan: Untuk mengetahui pengaruh modifi kasi gaya hidup pada reseptivitas endometrium perempuan obesitas dengan sindrom ovarium polikistik menggunakan ultrasonografi . Methods: This observational study was conducted at Dr. Cipto Mangunkusumo General Hospital Jakarta from August 2019 to May 2020. A total of 14 subjects were participated in this study. The subjects were advised to get nutrition counseling by nutritionist and then followed up the endometrial profi les for 6 months by ultrasonography. Metode: Penelitian observasional ini dilakukan di Rumah Sakit Umum Cipto Mangunkusumo Jakarta dari Agustus 2019 hingga Mei 2020. Sebanyak 14 subjek berpartisipasi dalam penelitian ini. Semua subyek disarankan untuk mendapatkan konseling gizi oleh ahli gizi dan dilakukan observasi profi l endometrium selama 6 bulan dengan ultrasonografi . Results: A total 19 subjects were received nutrition counseling by Clinical nutritionist, but then, only 14 subjects were evaluated the endometrial study by Ultrasonography. There were several signifi cant result between before and after treatment some subjects such as calories, body weight, body mass index, waist circumference (p<0.05) and type of the endometrial vascular zone, endometrium volume, and vascular fl ow index by ultrasonography (p<0.05). In this study, no signifi cant results have been found on the correlation between dietary changes and changes in endometrial receptivity profi les. Hasil: Sebanyak 19 subjek menerima konseling gizi oleh ahli gizi klinis, tetapi kemudian, hanya 14 subjek yang dievaluasi profi l endometrium dengan Ultrasonografi . Ada beberapa hasil yang signifi kan antara sebelum dan sesudah perawatan beberapa subjek seperti kalori, berat badan, indeks massa tubuh, lingkar pinggang (p<0,05) dan tipe zona vaskular endometrium, volume endometrium, dan indeks aliran vaskular dengan ultrasonografi (p <0,05). Dalam penelitian ini, tidak ditemukan hasil yang signifi kan pada korelasi antara perubahan pola makan dan perubahan dalam profi l reseptivitas endometrium. Conclusions: No signifi cant correlation was observed between changes in anthropometrics and daily calorie intake with changes in endometrial vascular zones. Kesimpulan: Tidak ada korelasi yang signifi kan antara perubahan antropometrik dan asupan kalori harian dengan perubahan zona vaskular endometrium. Keywords: endometrial receptivity, obese, polycystic ovary syndrome, ultrasonography. Kata kunci: endometrium, obesitas, reseptivitas, sindrom ovarium polikistik, ultrasonografi .