Effi cacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive IVA Result

Abstract

Effi cacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive IVA Result Efi kasi Trichloroacetic Acid (TCA) Dibandingkan Krioterapi sebagai Terapi Pasien dengan IVA Positif Herdhana Suwartono, Andrijono Department of Obstetrics and Gynecology Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Jakarta Abstract Abstrak Objective: To investigate the effectiveness TCA 85% compared to cryotherapy to treat patients with positive IVA result. Tujuan: Mengetahui efi kasi TCA 85% pada tatalaksana IVA positif dibandingkan dengan krioterapi. Metode: Penelitian ini merupakan penelitian randomized control trial menggunakan metode non-inferiority study. Subyek penelitian ini merupakan pasien dengan hasil IVA positif yang dirujuk ke Puskesmas Kecamatan Jatinegara, Jakarta Timur. Tatalaksana yang diberikan ditentukan menggunakan metode random block sampling. Subyek diikuti selama 3 bulan setelah tindakan untuk menentukan hasil konversi pemeriksaan IVA. Methods: This is a non-inferiority randomized controlled trial study. Patients with positive VIA result referred to Jatinegara Primary Health Center were included in this study. Eligible samples were then treated with either TCA 85% or cryotherapy. The treatment was determined using a random block sampling method. Samples were then followed up 3 months after treatment in order to determine VIA result conversion. Results: Thirty-six patients were treated with TCA 85% and 36 others were treated with cryotherapy. 35 (97,2%) patients treated with TCA 85% converted to negative VIA, whereas all of the patients that were treated with cryotherapy converted to negative VIA. Bivariate analysis fi sher’s exact test was then conducted with a result P-value of 1.00 (p > 0,05). Hasil: Sebanyak 36 subjek diterapi dengan TCA 85% dan 36 lainnya diterapi dengan krioterapi. Sebanyak 35 (97,2%) pasien yang ditatalaksana dengan TCA 85% mengalami konversi menjadi IVA negatif pada follow-up bulan ke3, sedangkan seluruh pasien yang ditatalaksana dengan

krioterapi menjadi konversi menjadi IVA negatif. Dilakukan

analisis bivariat fi sher’s exact test dan didapatkan nilai p

sebesar 1,00 (p>0,05). Conclusions: There was no statistically signifi cant difference of result between TCA 85% and cryotherapy for treating patients with positive VIA result. Kesimpulan: Tidak ada perbedaan bermakna dari efi kasi penggunaan TCA 85 % dibandingkan dengan krioterapi pada terapi IVA positif. Keywords: cervical cancer, cryotherapy, TCA 85%, VIA test. Kata kunci: kanker serviks, krioterapi, pemeriksaan IVA, TCA 85%.