Accuracy Tests of Serum Vitamin D and Calcium Levels in Chorioamnionitis Patients with Preterm Labor

Abstract

Accuracy Tests of Serum Vitamin D and Calcium Levels in Chorioamnionitis Patients with Preterm Labor Uji Kesesuaian Kadar Serum Vitamin D dan Kalsium pada Korioamnionitis Pasien Partus Prematur Muhammad F. C. Husna 1 1 , Peby M. Lestari 1 , Ahmad K. Syamsuri Departement of Obstetrics and Gynecology Medical Research Unit Faculty of Medicine Universitas Sriwijaya 2 Dr. Moh. Hoesin General Hospital Palembang Objective: To compare the sensitivity and specifi city of the diagnosis of chorioamnionitis in preterm labor using serum vitamin D and calcium in Dr.Mohammad Hoesin Hospital Palembang. Methods: This diagnostic test was carried out in the Obstetrics and Gynecology Department of Dr. Mohammad Hoesin Hospital Palembang from October 2018 to April 2019. Research subjects were women in preterm labor with chorioamnionitis. We collected 39 samples and 36 of them met the inclusion criteria. Results: Eighteen patients with hypovitaminosis vitamin D had chorioamnionitis with a sensitivity value of 94.74%, specifi city 5, 88%, positive predictive value (PPV) 52.9% and Negative Predictive Value (NPV) 50%. Two of the 4 patients with hypocalcemia had chorioamnionitis with sensitivity of 10.53%, specifi city 88. 24%, Positive Predictive Value (PPV) 50% and Negative Predictive Value (NPV) 46. 9%. Conclusions: Reliability of diagnosis accuracy of serum vitamin and calcium levels against chorioamnionitis is poor. Keywords: accuracy tests, calcium, chorioamnionitis, vitamin D. Abstrak Correspondence author: Muhammad F.C. Husna. muhammadfauzichairulhusna@gmail.com 1 , Theodorus 2 Tujuan: Membandingkan sensitivitas dan spesifi sitas diagnosis korioamnionitis pada partus prematurus antara serum vitamin D dan kalsium di Rumah Sakit Dr. Mohammad Hoesin Palembang. Metode: Uji diagnostik dilakukan di Departemen Obstetrik dan Ginekologi RSUP Dr. Mohammad Hoesin Palembang. Penelitian dilaksanakan sejak Oktober 2018 hingga April 2019. Subjek penelitian adalah perempuan hamil prematur yang didiagnosa korioamnionitis. Terdapat 39 sampel dimana 36 sampel termasuk kriteria inklusi. Hasil: Terdapat 18 pasien dengan hipovitaminosis vitamin D memiliki luaran koriaoamnionitis memiliki nilai sensitivitas 94,74%, spesifi sitas 5, 88%, positive predictive value (PPV) 52, 9% dan Negative Predictive Value (NPV) 50%. 2 dari 4 pasien dengan hipokalsemia memiliki luaran korioamnionitis memiliki sensitivitas 10, 53%, spesifi sitas 88, 24%, Positive Predictive Value (PPV) 50% dan Negative Predictive Value (NPV) 46, 9%. Kesimpulan: Akurasi diagnosis kadar serum vitamin dan kalsium terhadap luaran korioamnionitis memiliki derajat kesesuaian (realiabilitas) kurang baik. Kata kunci: kalsium, korioamnionitis, uji kesesuaian, vitamin D