Serum Vascular Endothelial Growth Factor Levels and Uterine Fibroid Volume

Abstract

Serum Vascular Endothelial Growth Factor Levels and Uterine Fibroid Volume Hubungan Kadar Serum Vascular Endothelial Growth Factor dengan Volume Mioma Uteri Rajuddin Rajuddin, Ronald Oscar, Tengku P. Dewi Department of Obstetrics and Gynecology Faculty of Medicine Universitas Syiah Kuala Dr. Zaenal Abidin General Hospital Banda Aceh Objective: To investigate the correlation of serum Vascular Endothelial Growth Factor (VEGF) levels and uterine fi broid volume. Methods: Observational analytic study was carried out on 80 patients with uterine fi broids indicated myomectomy. Each sample was examined for VEGF levels and volume of myoma tissue post myomectomy was measured by using Archimedes' law. Correlation test using the Spearman test. Results: A total of 80 samples of patients were examined for VEGF levels and uterine fi broids volume. The median VEGF is 360 pg/mL, the median uterine fi broids volume is 325 ml. The Spearman’stest shows p values (<0.01) and r (0.999). Conclusions: There is a signifi cant correlation between VEGF levels and uterine fi broids volume. The higher the VEGF level, the greater the volume of uterine fi broids. Keywords: archimedes law, uterine fi broids volume, VEGF. Abstrak Tujuan: Untuk mencari adanya korelasi antara kadar VEGF terhadap volume mioma uteri. Metode: Penelitian ini berupa analitik observasional. Sampel yaitu pasien dengan mioma uteri yang diindikasikan tindakan miomektomi. Setiap sampel diperiksa kadar VEGF dan pascamiomektomi dilakukan pengukuran volume terhadap jaringan mioma dengan menggunakan hukum Archimedes. Uji korelasi menggunakan Spearman test. Hasil: Sebanyak 80 sampel penderita mioma uteri diperiksa kadar VEGF kemudian dilakukan tindakan miomektomi. Median VEGF adalah 360 pg/mL, median volume uteri adalah 325 ml, uji korelasi Spearman didapatkan nilai p (<0,01) dan r (0,999). Kesimpulan: Terdapat korelasi antara kadar VEGF dengan volume mioma uteri, semakin tinggi kadar VEGF maka semakin besar volume mioma uteri. Kata kunci: hukum Archimedes, VEGF, volume mioma uteri