Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

Abstract

Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis Kadar vitamin D yang Rendah Meningkatkan Risiko Sepsis Neonatal Awitan Dini Abstract 1 Lisnawati Yuyun, 2 1 Ali Sungkar, 2 3 Rinawati Rohsiswatno, Denni Hermartin, 2 Agustin Kindi Department of Obstetrics and Gynecology Persahabatan Hospital, Jakarta Department of Obstetrics and Gynecology 2 Department of Pediatrics Faculty of Medicine Universitas Indonesia 3 Dr. Cipto Mangunkusumo General Hospital, Jakarta Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of EarlyOnset of Neonatal Sepsis (EONS) in newborns from mothers with Preterm Premature Rupture of Membranes (PPROM). Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta. Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a signifi cant association between maternal and umbilical cord vitamin D levels with EONS. Conclusions: There was a signifi cant association between maternal and umbilical cord vitamin D levels with EONS. Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D. Abstrak Correspondence author. Denni Hermartin. deny.hermatin@gmail.com INTRODUCTION The common cause (70%) of perinatal death was preterm birth. Preterm neonates often failed to adapt to new environment, causing high morbidity and mortality. It was important to decrease neonatal (0-28 days of age) mortality rate because it was contributed to 59% of infant mortality. Indonesian Demographic and Health Survey 2012 showed the neonatal mortality rate during 2012 was 19 per 1.000 live births. 1,2 Based on RISKESDAS 2007, neonatal sepsis (12%) was one of the common cause of neonatal death during 0-6 days of life besides respiratory 3 2 Noroyono Wibowo, Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD). Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil: Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan: Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kata kunci: ketuban pecah dini, sepsis neonatal awitan dini, vitamin D.