Birth defects associated with obesity

Abstract

Birth defects associated with obesity Ovadya Rosenbluh1, *, Asnat Walfisch2 1Obstetrics & Gynecology, The Chaim Sheba Medical Center, Derech Sheba 2, 52 621 Ramat-Gan, Israel 2Obstetrics & Gynecology, Hadassah Medical Center, 91120 Jerusalem, Israel *Correspondence: ovadyar@gmail.com; Ovadia.Rozanblo@sheba.health.gov.il (Ovadya Rosenbluh) DOI:10.31083/j.ceog.2021.03.2377 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: 23 November 2020 Revised: 15 January 2021 Accepted: 29 January 2021 Published: 15 June 2021 Background: In women of reproductive age, obesity is the most common medical condition. A condition which is increasing in prevalence worldwide. Obesity during pregnancy could have both short- and long-term adverse consequences for both mother and child. Methods: In this narrative review we discuss the most prominent observational studies and meta-analyses focusing on the association between maternal obesity (and BMI) and fetal congenital anomalies. Possible pathophysiological pathways linking the two are also discussed. Results: Obese women were found to have an increased at-birth prevalence of a wide range of fetal anomalies. These include congenital heart anomalies and neural tube defects, with a possible “doseresponse” correlation. The reasons for that may include increased insulin resistance in early pregnancy and nutritional deficiencies, but also probably result from the challenges of fetal anomaly detection during a detailed ultrasound in obese women. Discussion: A large array of different fetal anomalies have been found to be increased in the maternal obese population. The incidence of fetal neural tube defects and serious heart anomalies among the obese population might grow by 30%. Congenital anomalies are known to be a major cause of stillbirth and infant mortality, and are important contributors to preterm delivery and childhood morbidity. The possible dose response pattern observed between the severity of obesity and teratogenic potential necessitates further investigation, which may also shed light on the underlying pathophysiology. The increasing prevalence of obesity in general and particularly in the pregnant population may thus have serious health implications. Education regarding the many risks associated with obesity, for mothers and their babies, are warranted. Keywords Obesity; Pregnancy; Anomalies