Maternal serum pregnancy-associated plasma protein-A concentration at 11--14 weeks of gestation of women with common congenital anatomic uterine abnormalities

Abstract

Maternal serum pregnancy-associated plasma protein-A concentration at 11--14 weeks of gestation of women with common congenital anatomic uterine abnormalities Sotirios Sotiriou1, *, Maria Satra2 , Dimitra N. Vamvakopoulou3 , Chrisostomos Sofoudis4 , Aikaterini Simou5 , Thomas Kilindris6 , Andreas Sidiropoulos2 , Konstantinos V. Kakavas7 , Antonis Garas5 , Hara Skentou1 , Nikos C. Vamvakopoulos2 , Alexandros Daponte5 1 Laboratory of Histology and Embryology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece 2 Laboratory of Biology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece 3Department of Pediatrics and Neonatology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece 4Deptartment of Obstetrics and Gynecology, Konstandopoulio General Hospital, GR-11472 Athens, Greece 5Department of Obstetrics and Gynaecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece 6 Laboratory of Medical Informatics, School of Health Sciences, Faculty of Medicine, University of Thessaly, GR-41500 Larissa, Greece 7 Laboratory of Environmental quality and human health, Department of Environment, University of Thessaly, GR-41500 Larissa, Greece *Correspondence: sotiriousoti@yahoo.gr (Sotirios Sotiriou) DOI:10.31083/j.ceog.2021.02.2319 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: 08 October 2020 Revised: 23 November 2020 Accepted: 25 November 2020 Published: 15 April 2021 Objectives: To evaluate maternal serum pregnancy-associated plasma protein-A (PAPP-A) levels at 11--14 weeks of gestation in women with common congenital anatomic uterine abnormalities (AUAs). Methods: First trimester screening markers were compared between 12 AUA pregnancies and 60 age matched controls. Results: PAPP-A level and birth weight were significantly lower in AUA compared to control pregnancies (P < 0.001). Conclusion: Our findings suggest that AUA pregnancies are associated with low first trimester maternal serum PAPP-A concentrations. Keywords Pregnancy-associated plasma protein A; PAPP-A; Congenital anatomic uterine abnormalities; AUA