Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis

Abstract

Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis Yi Zhou1 , Ran Wang2 , Shi-Xian Chen2 , Li-Sheng Wu2,3, *, Jun-Qing Zhu2, * 1Department of Obstetrics, Guangdong Women and Children Hospital, 510510 Guangzhou, Guangdong, China 2Department of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, 510510 Guangzhou, Guangdong, China 3Department of Internal Medicine of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Southern Medical University, 510510 Guangzhou, Guangdong, China *Correspondence: jqzhujq@yeah.net (Jun-Qing Zhu);wlslu@smu.edu.cn (Li-Sheng Wu) DOI:10.31083/j.ceog.2021.02.2265 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: 20 August 2020 Revised: 03 November 2020 Accepted: 16 November 2020 Published: 15 April 2021 Hypertensive disorders of pregnancy (HDP) encompass a group of diseases. Single nucleotide polymorphisms (SNPs) are common in the matrix metalloproteinase 9 (MMP9) genes. The objective of this study was to analyse whether genetic polymorphisms in MMP9-1562 C/T alter the risk of HDP. Studies published up to October 2019 across PubMed, ScienceDirect, SpringerLink, and China National Knowledge Infrastructure database were searched. Case-control or cohort studies involving subtypes of HDP and distribution of genotypes and/or alleles within MMP9-1562 C/T in both patients and controls were selected. Number of genotypes and/or alleles for MMP9-1562 C/T polymorphisms were obtained and analyzed using Stata soȻtware. Eight published reports including 1300 HDP patients and 1612 controls were included in the meta-analysis. Results showed that a variant genotype and allele of MMP9-1562 C/T increased the risk of HDP, with pooled OR 1.50 (95% CI 1.16--1.95, P = 0.002) and 1.36 (95% CI 1.15--1.61, P < 0.001). Subgroup analyses showed that the variant genotype and allele of MMP9-1562 C/T also had increased risk of preeclampsia (OR = 1.48, 1.32; 95% CI 1.18--1.86, 1.08--1.62; P = 0.001, 0.007) and gestational hypertension (OR = 2.23, 1.88; 95% CI 1.52-- 3.28, 1.33--2.65; P < 0.001, < 0.001) in the fixed-eȞfects models. This suggests that variant genotype (TT + TC) and allele (T) of MMP9-1562 C/T are associated with susceptibility of HDP, especially preeclampsia and gestational hypertension. Keywords Hypertensive disorders of pregnancy; Gestational hypertension; Preeclampsia; Matrix metalloproteinase 9; Single nucleotide polymorphism