Profile Changes in Weight and Body Mass Index of Single Rod Levonorgestrel Implant Acceptor (Monoplant®)

Abstract

Profile Changes in Weight and Body Mass Index of Single Rod Levonorgestrel Implant Acceptor (Monoplant®) Profil Perubahan Berat Badan dan Indeks Massa Tubuh Akseptor Implan Levonorgestrel Satu Batang (Monoplant®) Eka R. Gunardi, Jimmy T. Sitorus Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Objective: To finding out the change of weight and body mass index (BMI) of single rodlevonorgestrel implant acceptor (Monoplant ). Methods: A cross-sectional descriptive study was ® conductedusing data changes of weight and BMI obtained from series of measurement which is recorded in patients’ medical record in three years of Monoplant placement in Raden Saleh Clinic, Jakarta. This method is the part of a research of a bigger phase two in clinical test. ® Results: From 21 subjects of this research, the average weight and BMI before and after 3 years of Monoplant placement is gained, i.e. 53.1 (SD 11,0) kg and 22.4 (SD 4.5) kg/m2, and 54.8 (SD 9.4) kg and 23.1 (SD 3.9) kg/m2. Despite the tendency of increasing, statistically the increasing of weight and BMI, however, is meaningless (p=0.09) and (p=0.08). There is a difference of weight in series of measurement, particularly after the 12th month (Repeated test ANOVA p=0.024). Even though there is no difference in BMI average, there is a difference in subject's proportion based on BMI categories before and after Monoplant ® ® placement (Marginal homogeneity test p=0.046). The increasing of levonorgestrel level occurs in the 6th month and subsequently followed by the increase of BMI in the 12 month. Conclusions: There is a tendency of increasing weight and BMI in Monoplant ® th users, specifically after one year despite statistically insignificant. Keywords: levonorgestrel, monoplant , weight, body mass index. ® Jakarta Abstrak Tujuan: Untuk mengetahui perubahan berat badan dan indeks massa tubuh pada akseptor implan levonorgestrel satu batang (Monoplant ). Metode: Studi deskriptif dengan desain potong lintang Correspondence author. Eka R. Gunardi. eka_dhigita@yahoo.co.id ® mengambil data perubahan BB dan IMT diperoleh dari pengukuran serial yang tercatat dalam rekam medis pasien selama tiga tahun pemasangan Monoplant di Klinik Raden Saleh, Jakarta. Penelitian ini merupakan bagian dari suatu penelitian uji klinis fase 2 yang lebih besar. ® Hasil: Dari 21 subjek penelitian ini, didapatkan rerata BB dan IMT sebelum dan setelah 3 tahun pemasangan Monoplant yakni 53,1 (SB 11,0) kg dan 22,4 (SB 4,5) kg/ m2, serta 54,8 (SB 9,4) kg dan 23,1 (SB 3,9) kg/m2. Meskipun ada kecenderungan naik, tetapi secara statistik kenaikan BB dan IMT tersebut tidak bermakna (p=0,09) dan (p=0,08). Terdapat perbedaan berat badan dalam pengukuran serial, terutama setelah bulan ke-12 (Uji repeated ANOVA p=0,024). Walaupun tidak terdapat perbedaan rerata IMT, terdapat perbedaan proporsi subjek berdasarkan kategori IMT sebelum dan setelah pemasangan Monoplant ® (Uji Marginal homogeinity p=0,046). Peningkatan kadar levonorgestrel terjadi pada bulan ke-6 yang kemudian diikuti oleh kenaikan IMT pada bulan ke-12. ® Kesimpulan: Terdapat kecenderungan peningkatan BB dan IMT pengguna Monoplant , khususnya setelah satu tahunmeskipun secara statistik tidak bermakna. ® Kata kunci: berat badan, indeks massa tubuh, levonorgestrel, monoplant . ®