The effect of oral vitamin E supplementation on infertile women: a systematic review and meta-analysis

Abstract

The effect of oral vitamin E supplementation on infertile women: a systematic review and meta-analysis Jia-Hui Wu1,2,† , Dan-Ni Yang1,2,† , Li-Juan Cao1 , Jia-Qi Luo1 , Wei-Ping Qian1 , Wen-Min Ma3 , Xi Xia1, * 1 Center for Reproductive Medicine, Peking University Shenzhen Hospital, Futian District, 518000 Shenzhen, Guangdong, China 2 Shenzhen Maternal and Child Healthcare Hospital Affiliated to Southern Medical University, Futian District, 518000 Shenzhen, Guangdong, China 3 Foshan Women and Children Hospital, 528000 Foshan, Guangdong, China *Correspondence: xixia1126@hotmail.com (Xi Xia) † These authors contributed equally. DOI:10.31083/j.ceog.2021.02.2207 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: 01 July 2020 Revised: 11 September 2020 Accepted: 23 September 2020 Published: 15 April 2021 This study was aimed to investigate the eȞfect of vitamin E (Vit E) supplementation on endometrial thickness and pregnancy outcomes in infertile women. The literature was screened by two researchers and the data was extracted by searching published literature from 1999 to 2020 in the Cochrane library, PubMed, and Embase database. Seven clinical trials were included, with a total of 652 subjects. Here we found the mean endometrium was thicker in Vit E treatment group than that in the control group [SMD = 0.57, 95% CI (0.26, 0.87), P = 0.0002]. Subgroup analysis showed that no significant eȞfect between administration of 400 IU (267 mg) or 100 mg Vit E per day. There was no significant diȞference between with or without Vit E on ongoing pregnancy rate [OR = 1.08, 95% CI (0.72, 1.62), P = 0.70]. The current evidence demonstrates that Vit E supplementation may increase endometrial thickness in women of reproductive age. Keywords Vitamin E supplementation; Endometrial thickness; Ongoing pregnancy; Systematic review