Profi le of D-dimer in Uncomplicated Pregnancy

Abstract

Profi le of D-dimer in Uncomplicated Pregnancy Profi l D-dimer Kehamilan tanpa Komplikasi Rahajuningsih Dharma 3 2 1 1 , Mercy T Panjaitan 1 , Kanadi Sumapradja

Rianto Setiabudy 3 Department of Clinical Pathology Department of Obstetric Gynecology Department of Pharmacology and Therapy Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital, Jakarta Objective : To obtain the profi le of D-dimer in uncomplicated pregnancy. Methods : A cross sectional study was done on 90 uncomplicated pregnant women consisted of 30 women in each trimester and 30 healthy, nonpregnant women as control group from July to August 2012. D-dimer level was measured by particle enhanced immunoturbidimetry method using Innovance D-dimer and Sysmex CA 1500 in the Department of Clinical Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta. Results : All women in the control group showed normal D-dimer level (<0.,5 mg/L FEU). The median and range of D-dimer level in the 1 st trimester, 2 nd trimester, and 3 trimester were 0.42 mg/L FEU and 0.1-1.07 mg/L FEU, 0.97 mg/L FEU and 0.6-3.34 mg/L FEU, and 1.56 mg/L FEU and 0.69-3.75 mg/L FEU, respectively. Increased D-dimer level was found in 27% of pregnant women in 1 trimester, 87% in 2 nd trimester, and 100% in 3 rd st trimester. Conclusions : Increased D-dimer level was found in 27% of pregnant women in 1 st trimester, 87% in 2 trimester, and 100% in 3 rd nd trimester. The range of D-dimer level in the 1 trimester was 0.1-1.07 mg/L FEU, in the 2 trimester was 0.6-3.34 mg/L FEU, and in the 3 rd nd trimester was 0.69-3.75 mg/L FEU. Keywords : D-dimer, trimester, uncomplicated pregnancy. rd st Abstrak Correspondence author: Rahajuningsih Dharma; rahaset@yahoo.com 2 Tujuan : Untuk mendapatkan profi l D-dimer pada kehamilan tanpa komplikasi. Metode : Penelitian potong lintang dilakukan pada 90 perempuan hamil tanpa komplikasi yang terdiri atas 30 perempuan pada tiap trimester dan 30 perempuan sehat yang tidak hamil, sebagai kelompok kontrol dari bulan Juli sampai Agustus 2012. Kadar D-dimer diukur dengan cara particle enhanced immunoturbidimetry menggunakan reagen Innovance® D-dimer dan koagulometer Sysmex® CA 1500 di Deparemen Patologi Klinik, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Jakarta. Hasil : Seluruh perempuan dalam kelompok kontrol mempunyai kadar D-dimer dalam batas normal (<0.,5 mg/L FEU). Median (rentang) kadar D-dimer pada trimester pertama, kedua, dan ketiga berturut-turut 0.42 mg/L FEU (0.1-1.07 mg/L FEU), 0.97 mg/L FEU (0.6-3.34 mg/L FEU), dan 1.56 mg/L FEU (0.69-3.75 mg/L FEU). Peningkatan kadar D-dimer ditemukan pada 27% perempuan hamil trimester pertama, 87% trimester kedua, dan pada 100% trimester ketiga. Kesimpulan : Peningkatan kadar D-dimer ditemukan pada 27% perempuan hamil trimester pertama, 87% trimester kedua dan 100% pada trimester ketiga. Rentang kadar D-dimer level pada trimester pertama adalah 0.1-1.07 mg/L FEU, pada trimester kedua 0.6-3.34 mg/L FEU, dan pada trimester ketiga 0.69-3.75 mg/L FEU. Kata kunci : D-dimer, kehamilan tanpa komplikasi, trimester