Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study

Abstract

Effects of intrauterine autologous platelet-rich plasma infusions on outcomes in women with repetitive in vitro fertilization failures: a prospective randomized study Mahvash Zargar1, *, Razieh Pazhouhanfar1 , Mahin Najafian1 , Parastoo Moradi Choghakabodi2 1Department of Obstetrics and Gynecology, Fertility Infertility and Perinatology Research Center, AhvazJundishapur University of medical sciences, 61357-15794 Ahvaz, Iran 2AhvazJundishapur University of Medical Sciences; Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, 61357-15794 Ahvaz, Iran *Correspondence: Zargar_m@ajums.ac.ir (Mahvash Zargar) DOI:10.31083/j.ceog.2021.01.2131 This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). Submitted: May 07, 2020 Revised: November 09, 2020 Accepted: November 13, 2020 Published: February 15, 2021 Purpose: Evaluation of the eȞfect of platelet-rich plasma (PRP) containing platelet-derived growth factor on in vitro fertilization (IVF) failure patients. Methods: In this clinical trial, 80 eligible patients (infertile women with at least two IVF failures) were randomly assigned into two groups, including patients who received an intrauterine infusion of PRP (n: 40) and controls (n: 40). Before PRP therapy, standard hormone replacement therapy was performed for all patients to endometrial thickness preparation. AȻter sonographic assessment of endometrium, PRP was injected into all patients' endometrium whether they had an appropriate endometrial thickness or not. Then, the embryo transferring was done through IVF. Eventually, the consequences of fertility, embryo implantation, and pregnancy were evaluated. Data analysis was performed using SPSS version 22. Results: The rate of successful IVF [6 (15%)], pregnancy rate [5 (12.5%)], and live birth [5 (12.5%)] were relatively higher in patients undergoing PRP therapy compared with controls [2 (5%), 1 (2.5%) and 0, respectively]. However, their statistical diȞference was not significant between the two groups (P > 0.05). Conclusion: Our findings suggest that endometrial injection of platelet-rich plasma for IVF failure patients did not significantly improve the IVF process, pregnancy, and live birth rates. Keywords Platelet-rich plasma; Platelet-derived growth factor; In vitro fertilization; Pregnancy rate; Live birth; Women