Exploration on the relationship between hypoxia inducible factor-1 and morbidly adherent placenta

Abstract

Exploration on the relationship between hypoxia inducible factor-1 and morbidly adherent placenta J.Y. Yan1;†; , P.P. Chen2, L.L. Jiang1;†, H.L. Zhang1, Q. Han1, R.X. Chen1, Q.J. Zhang1 1Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001 (P.R. China) 2Second affiliated hospital of Fujian medical university, Quanzhou, Fujian, 362001 (P.R. China) Summary Objective: This study aims to explore the role of hypoxia inducible factor-1 (HIF-1 ) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of HIF-1 in the placenta. Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the HIF-1 protein levels in the placenta. Results: The mean expression of placental HIF-1 in the placenta increta and placenta previa groups was significantly higher than that in the normal placenta. The level of placental HIF-1 in the placenta increta was significantly higher than that in the placenta previa (p < 0.05). The level of placental HIF-1 had no obvious correlation with the accreta site and umbilical cord insertion. Conclusion: The morbidly of adherent placenta is closely correlated to adverse pregnancy outcomes during the perinatal period. Placental HIF-1 is associated with morbidly adherent placenta. Key words: HIF-1 ; Placenta increta; Placenta previa; Pathogenesis; Morbidly adherent placenta.