The Role of Maternal Progesterone and Estradiol Levels in Predicting the Success of Induction of Labour : A Preliminary Study

Abstract

The Role of Maternal Progesterone and Estradiol Levels in Predicting the Success of Induction of Labour : A Preliminary Study Hubungan Kadar Progesteron dan Estradiol Ibu terhadap Keberhasilan Induksi Persalinan : Suatu Studi Pendahuluan Kanadi Sumapraja, Hilda R Badruddin Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Jakarta Abstract Abstrak Objective : to evaluate whether maternal progesterone and estradiol levels could be used to predict the success of induction of labour (IOL). Tujuan : mengevaluasi kadar progesteron dan estradiol ibu sebagai prediktor kesuksesan induksi persalinan. Methods : This cross-sectional study was conducted at the Women's Health Clinic as well as the delivery suite of Dr. Cipto Mangunkusumo Hospital during the period of May 2016 to April 2017. Blood samples of term pregnant women who were indicated for IOL were obtained before birth. Metode : Penelitian ini menggunakan desain potong lintang yang berlangsung pada bulan Mei 2016 hingga April 2017 di Poliklinik dan IGD Kebidanan Rumah Sakit Umum Pusat Rujukan Nasional Cipto Mangunkusumo. Pasien hamil aterm yang dilakukan induksi persalinan dan memenuhi kriteria penelitian akan diambil sampel darah sebelum persalinan. Results : A total of 44 subjects were recruited in this study. Of these, 24 subjects had successful IOL while the other 20 subjects had IOL failure. There was no signifi cant difference in progesterone among both groups (66,7% vs 75%, p=0,55). The estradiol levels in subjects who successfully performed induction had an average of 16,916.28 ± 2,574.75 pg/mL which did not differ signifi cantly from the failed of induction group with estradiol levels of 14,832.24 ± 2374.47 pg/mL (p = 0,65). Hasil : Dari 44 subjek yang mengikuti penelitian, 24 subjek berhasil dilakukan induksi persalinan dan 20 subjek gagal. Tidak terdapat perbedaan bermakna pada kadar progesteron Antara kedua grup (66,7% vs 75%, p=0,55). Kadar estradiol pada pasien yang berhasil dilakukan induksi memiliki ratarata 16.916,28 + 2.574,75pg/mL yang tidak berbeda jauh

dengan kadar estradiol pasien yang gagal induksi yaitu

14.832,24 + 2374,47pg/mL (p = 0,65). Kesimpulan : Tidak terdapat perbedaan bermakna antara kadar progesteron dan estradiol maternal terhadap keberhasilan induksi persalinan. Penelitian lebih lanjut dengan jumlah sampel yang lebih besar dibutuhkan untuk mengkonfi rmasi hubungan ini dengan lebih baik. Conclusions : We found no signifi cant association between both maternal progesterone and estradiol levels and the success rate of IOL. Further studies with larger sample sizes are required to confi rm whether progesterone and estradiol play pivotal roles in the success of IOL. Kata kunci : estradiol, induksi persalinan, progesteron Keywords : estradiol, induction of labour, progesterone.