Estradiol Level and Psychosocial Stress in Perimenopausal Women

Abstract

Estradiol Level and Psychosocial Stress in Perimenopausal Women Kadar Estradiol dan Stres Psikososial pada Perempuan Perimenopause Lucia L L S Hadiprodjo,Nusratuddin Abdullah, Nugraha U Pelupessy Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo General Hospital Makassar Abstract Abstrak Objective : To determine the relationship between estradiol Tujuan : Untuk mengetahui hubungan antara kadar levels and psychosocial stress in perimenopausal women. estradiol terhadap stres psikososial pada perempuan Methods : Sixty perimenopausal included in a cross-sectional study from July to December 2016. Blood samples obtained from the women to measure the estradiol and the cortisol levels. Stress level measured with visual. Data presented as the mean and standard deviation (mean±SD) with p-value <.05 was considered statistically signifi cant. Results : There was no signifi cant difference between the estradiol levels and the stress level (p=0.27) during perimenopause period. The estradiol levels were higher compared with the cortisol levels. The non-parametric correlations analysis show that the estradiol levels were not correlated with the cortisol levels (p=0.352). However, the cortisol levels were correlated with the stress levels (p<0.05). Conclusions : Estradiol does not cause psychosocial stress during perimenopause period in our study population. Keywords : estradiol, perimenopause, psychosocial stress. perimenopause. Metode : Enam puluh perempuan perimenopause dilibatkan penelitian potong lintang dari Juli sampai Desember 2016. Sampel darah diperoleh dari perempuan untuk mengukur kadar estradiol dan kortisol. Tingkat stres diukur dengan visual analog scale (VAS). Data yang disajikan sebagai rerata dan standar deviasi (mean±SD) dengan tingkat kemaknaan 0,05. Hasil : Tidak ada perbedaan yang signifi kan antara kadar estradiol dan tingkat stres (p=0,27) selama periode perimenopause. Kadar estradiol lebih tinggi dibandingkan dengan kadar kortisol. Analisis korelasi non parametrik menunjukkan kadar estradiol tidak berkorelasi dengan kadar kortisol (p= 0,352). Namun, kadar kortisol berkorelasi dengan tingkat stres (p<0,05) perempuan perimenopause. Kesimpulan : Estradiol tidak menyebabkan stres psikososial selama periode perimenopause pada populasi penelitian kami. Kata kunci : estradiol, perimenopause, stres psikososial