Correlation between Body Mass Index and Lipid Profi le in Second Trimester with the Incidence of Hypertension in Third Trimester

Abstract

Correlation between Body Mass Index and Lipid Profi le in Second Trimester with the Incidence of Hypertension in Third Trimester Hubungan Indeks Massa Tubuh dan Profi l Lipid Trimester Kedua dengan Kejadian Hipertensi pada Trimester Ketiga Ananto Prasetyo, John J E Wantania, Erna Suparman Department of Obstetrics and Gynecology Faculty of Medicine Universitas Sam Ratulangi Prof.Dr.R.D Kandou General Hospital Manado Abstract Abstrak Objective : To determine the relationship of BMI (Body Mass Index) and lipid profi le (total cholesterol, triglycerides, HDL, LDL, VLDL) in the second trimester of pregnancy with the incidence of hypertension in the third trimester of pregnancy. Tujuan : Untuk mengetahui hubungan IMT (Indeks Massa Tubuh) dan profi l lipid ( kolesterol total, trigliserida, HDL, LDL, VLDV) pada trimester kedua kehamilan dengan kejadian hipertensi pada trimester ketiga kehamilan. Metode : Penelitian ini merupakan kohort prospektif. Subjek penelitian adalah kelompok ibu hamil trimester kedua yang diperiksa IMT dan profi l lipidnya, kemudian dinilai kejadian hipertensi pada trimester ketiga. Penelitian dilakukan di Departemen Obstetri dan Ginekologi Rumah Sakit Umum Pusat (RSUP) Prof.DR.R.D Kandou, dan RS jejaring mulai Januari 2017 sampai Mei 2017. Data dianalisa dengan SPSS versi 2.0 Methods : This was a prospective study. Subjects were the second-trimester pregnant women group which examined by BMI and lipid profi le, then assessed the incidence of hypertension in the third trimester. The study was conducted in the Department of Obstetrics and Gynecology and Prof. DR.RD Kandou General Hospital, and affi liated hospital from January 2017 until May 2017. Data analysed with SPSS version 2.0 Results : Of 49 subjects, based on age, most subject with age 20-34 years with 42 subjects (85.8%). Based on the parity obtained 27 subjects (55.2%) with multigravida. By education level, most are high school with 19 subjects (38.7%). From the occupation, most are housewives with 30 subjects (61.3%). Based on BMI, most were subjects with normal BMI with 21 subjects (42.9%). Pearson test showed a signifi cant association between BMI with total cholesterol (r = 0.500 and p = 0.000), whereas Spearman test showed signifi cant relation between BMI with LDL cholesterol (r = 0.416 and p = 0.003) and signifi cant relation between second-trimester LDL cholesterol with third trimester diastolic blood pressure(r = 0.303 and p = 0.034). Hasil : Dari 49 subjek penelitian, berdasarkan usia paling banyak usia 20 – 34 tahun dengan 42 subjek (85,8%). Berdasarkan paritas didapatkan 27 subjek (55,2%) dengan multigravida. Berdasarkan pendidikan, paling banyak adalah SMA dengan 19 subjek (38,7%). Dari jenis pekerjaan, paling banyak adalah ibu rumah tangga dengan 30 subjek (61,3%). Berdasarkan IMT, paling banyak adalah subjek dengan IMT normal dengan 21 subjek (42,9%). Uji Pearson menunjukkan hubungan bermakna antara IMT dengan kolesterol total (r = 0,500 dan p = 0,000), sedangkan Uji Spearman menunjukkan hubungan bermakna antara IMT dengan kolesterol LDL (r = 0,416 dan p = 0,003) dan hubungan bermakna antara kolesterol LDL trimester kedua dengan tekanan darah diastol trimester ketiga (r = 0,303 dan p = 0,034). Conclusions : There was a signifi cant correlation between BMI with total cholesterol & LDL in the second trimester, and there was a signifi cant correlation between LDL in the second trimester and third-trimester diastolic blood pressure. Kesimpulan : Terdapat hubungan bermakna antara IMT dengan kolesterol total, LDL trimester kedua dan terdapat hubungan bermakna antara LDL trimester kedua dengan tekanan darah diastol trimester ketiga. Keywords : BMI, HDL, hypertension, LDL, TG, VLDL, total Kata kunci : HDL, hipertensi, IMT, kolesterol total, LDL,VLDL, TG cholesterol