Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients

Abstract

Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients Perbandingan Tingkat Kesesuaian Hasil Identifi kasi Human Papilomavirus Tipe 16 dan 18 antara Spesimen Serviks dan Oral pada Penderita Kanker Serviks Willy Akbar, Syahrul Rauf, Deviana S. Riu, St. Maisuri T. Chalid Department of Obstetrics and Gynecology Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo General Hospital Makassar Abstract Abstrak Objective: To determine the conformity of HPV type 16 and 18 in cervical and oral/buccal specimens from cervical cancer patients. Tujuan: Mengetahui tingkat kesesuaian hasil pemeriksaan HPV tipe 16 dan 18 antara spesimen serviks dan oral/buccal pada penderita kanker serviks Methods: A cross-sectional study was conducted in March - September 2016 at several hospitals in Makassar. HPV 16 and 18 genotyping in cervical and oral fl uid of 77 patients with cervical cancer performed with PCR method. Metode: Penelitian potong lintang ini dilakukan pada Maret – September 2016 pada beberapa rumah sakit di Makassar. Pemeriksaan HPV 16 dan 18 pada cairan serviks dan oral dari 77 orang penderita kanker serviks menggunakan teknik PCR. Results: The prevalence of HPV type 18 infection both in the cervical and the oral fl uid was higher than HPV type 16 [9(47.4%) vs 5(26.3%)]. The agreement of HPV type 18 infection (r=0.328;p=0.000) in the cervical-oral sites was higher than HPV type 16 (r=0.194;p=0.042). Hasil: Prevalensi infeksi bersama pada serviks dan oral HPV tipe 18 lebih tinggi dibandingkan HPV tipe 16 [9(47,4%) vs 5(26,3%)]. Tingkat kesesuaian antara HPV tipe 18 (r=0,328;p=0,000) pada serviks dan oral lebih tinggi dibandingkan tipe 16 (r=0,194;p=0,042). Conclusions: HPV type 16 and 18 could infect both cervix and oral cavity although type-specifi c concordance is low. Kesimpulan: HPV tipe 16 dan 18 dapat menginfeksi serviks dan oral meskipun tingkat kesesuaian kedua tipe ini lemah. Keywords: cervix ,human papillomavirus, oral cavity, Kata kunci :human papillomavirus, kavum oral, serviks