Recurrent hydatidiform mole: when to stop ?

Abstract

Recurrent hydatidiform mole: when to stop ? E. Ozbasli1; , O. Takmaz1, H. Gurkan2, Y. Alanay1, M. Gungor1, F.S. Dede1 1Department of Obstetrics and Gynecology, Acibadem University School of Medicine, Istanbul (Turkey) 2Diagnostics Center for Genetic Diseases, University of Trakya, Trakya Medical Faculty, Edirne (Turkey) Summary Recurrent hydatidiform mole (RHM) is defined as two or more repeated molar pregnancies in the same patient. Familial recurrent hydatidiform mole (FRHM) is a rare condition in which the patient has relatives with the same condition and mutations. Maternal mutations in the NLRP7 gene are mostly observed in RHM. The authors report a patient from Turkey with a history of seven molar pregnancies who had an aunt with similar obstetric history and NLRP7 mutations. Key words: Familial hydatidiform mole; NLRP7; Ovum donation; Genomic imprinting.