The Proportion of Lymph Node Metastasis in Patients with Stage IIA 1and IIA2 Cervical Cancer who were Treated for Radical Hysterectomy and Pelvic Lymphadenectomy

Abstract

The Proportion of Lymph Node Metastasis in Patients with Stage IIA 1and IIA2 Cervical Cancer who were Treated for Radical Hysterectomy and Pelvic Lymphadenectomy Perbandingan Proporsi Metastasis Kelenjar Getah Bening pada Pasien Kanker Serviks Stadium IIA1 dan IIA2 yang Ditatalaksana Histerektomi Radikal dan Limfadenektomi Pelvis Andrijono, Wahyu Ginealdy Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Jakarta Abstract Abstrak Objective : This study was conducted to determine a difference in the prognosis of stage IIA1 cervical cancer compared to stage IIA2 based on the incidence of metastasis to pelvic lymph nodes by radical hysterectomy. Tujuan : Membuktikan adanya perbedaan prognosis kanker servik stadium IIA1 dibanding stadium IIA2 berdasarkan kejadian metastasis ke kelenjar getah bening pelvik yang dilakukan histerektomi radikal. Methods : A cross-sectional study was conducted among 108 stage II cervical cancer patients who had undergone radical hysterectomy in the obstetric-gynecologic department of Dr. Cipto Mangunkusumo hospital since 2006-2016. Metode : Dengan menggunakan metode potong lintang dilakukan pengambilan data 108 sampel pasien kanker serviks stadium IIA yang dilakukan pembedahan histerektomi radikal di Departemen Onkologi Ginekologi RSUP. Dr. Cipto Mangunkusumo Jakarta sejak tahun 2006 hingga tahun 2016. Results : Of 108 patients with cervical cancer stage IIA, 80 (74%) patients are stage IIA1 and the remaining the remaining 28 (26%) patients are stage IIA2. The average age of patients at stage IIA2 (47.79 years) younger than IIA1 (55.85 years) and also patient at stage IIA1 having a higher parity number which is four compared to stage IIA2 with the number of parity 2. The Involvement of lymph node metastasis in patients with stage IIA1 and IIA2 cervical cancer were 51 (63.75%) and 16 (57.14%) respectively. Hasil : Pasien kanker serviks stadium IIA1 sebanyak 80 (74%) pasien dan stadium IIA2 sebanyak 28 (26 %) pasien. Pada stadium IIA2 (47.79 tahun) didapatkan rata- rata usia pasien lebih muda dibandingkan IIA1 (55.85 tahun). Pada stadium IIA1 juga didapatkan jumlah paritas yang lebih tinggi yaitu 4 sedangkan pada stadium IIA2 dengan jumlah paritas 2. Keterlibatan metastasis kelenjar getah bening pada pasien kanker serviks stadium IIA1 dan IIA2 berjumlah 51 (63.75%) dan 16 (57.14%) secara berurutan. Tidak terdapat perbedaan proporsi kejadian metastasis kelenjar getah bening pada kedua kelompok stadium kanker serviks pada stadium IIA dengan nilai p = 0,535. Conclusions : Metastatic factor to lymph node in both stages have the same result. There was no difference in the proportion of lymph node metastasis occurring in both stage IIA cervical cancer stage which was corrected with radical hysterectomy and pelvic lymphadenectomy with p = 0.535. Changing staging did not seem to improve the prognosis. Kesimpulan : Faktor metastasis kelenjar getah bening pada kedua stadium memiliki hasil yang serupa.Tidak terdapat Keywords : cervical cancer, lymph node metastatic, stage IIA perbedaan proporsi kejadian metastasis kelenjar getah bening pada kedua kelompok stadium kanker serviks stadium IIA1 dan IIA2 yang ditatalaksna dengan histerektomi radikal dan limfadenektomi pelvis. Perubahan penetapan stadium sepertinya tidak memperbaiki prognosis. Kata kunci : faktor prognostik , kanker serviks, kelenjar getah bening, stage IIA.