The Associated of Serum Inhibin A Levels in Severe Preeclampsia

Abstract

The Associated of Serum Inhibin A Levels in Severe Preeclampsia Hubungan Kadar Inhibin A Serum pada Preeklamsia Berat Anastasia M Lumentut, Junneke J Kaeng, Eddy Suparman Department of Obstetrics and Gynecology Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R. D. Kandou Central General Hospital Manado Abstract Abstrak Objective: to prove the associated of serum Inhibin A levels in severe preeclampsia. Tujuan: untuk membuktikan hubungan kadar inhibin A serum pada preeclamsia berat. Methods : This was a cross-sectional study. Subjects consisted of 23 samples of normotensive pregnancy and 23 of samples severe preeclampsia who meet the inclusion and exclusion criteria. This study was conducted and evaluated from September 2016 until December 2016 at the Department of Obstetrics and Gynecology Faculty of Medicine University of Sam Ratulangi Prof. Dr. R. D. Kandou Hospital Manado and satellite hospitals. Samples were analysed using ELISA method at Prodia laboratory. Data were analysed with SPSS version 20.0 Metode: penelitian ini merupakan studi analitik observasional dalam bentuk desain potong lintang. Dilakukan pemeriksaan kadar Inhibin A serum pada 46 sampel ibu hamil yang memenuhi kriteria inklusi dan eksklusi, terdiri atas 23 kelompok preeclamsia berat dan 23 kelompok kehamilan normotesi. Penelitian dilaksanakan dan dievaluasi sejak bulan September 2016 sampai Desember 2016 di Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sam Ratulangi / RSU Prof. dr. R. D. Kandou Manado dan rumah sakit jejaring. Analisis sampel dilakukan di Laboratorium Prodia Jakartamenggunakan metode ELISA. Data dianalisis denganSPSS versi 20.0. Results: Mean serum Inhibin A levels in normotensive pregnancy is 477.22 pg/ml while mean in severe preeclampsia is 2712.39 pg/ml with p-value = 0.000. Hasil: rerata kadar Inhibin A serum pada kelompok kehamilan normotesi yaitu 477,22 pg/ml sedangkan rerata pada kelompok preeklamsia berat yaitu 271,39 pg/ml dengan nilai p=0,000. Conclusions: Levels of serum Inhibin A in severe preeclampsia cantly higher compared to normotensive pregnancy. Keywords: inhibin A, normotensive, severe preeclampsia Kesimpulan: kadar Inhibin A serum pada preeklamsia berat lebih tinggi secara bermakna dibandingkan dengan kehamilan normotensi. Kata kunci: inhibin A, normotensi, preeklamsia berat