Serum Lipid Profi le in Pregnancy and Postpartum Severe Preeclampsia

Abstract

Serum Lipid Profi le in Pregnancy and Postpartum Severe Preeclampsia Profi l Lipid Serum pada Preeklamsia Berat dalam Kehamilan dan Postpartum Putu F I White, John J E Wantania, Maya E Mewengkang Department of Obstetrics and Gynecology Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D Kandou Central General Hospital Manado Abstract Abstrak Objective: To investigate the associationbetween serum lipid profi le (total cholesterol, triglyceride, HDL, LDL, VLDL) andpregnancy as well as postpartum severe preeclampsia. Tujuan: Untuk mengetahui hubungan profi l lipid serum (kolesterol total, trigliserida, HDL, LDL, VLDL) dengan preeklamsia dalam kehamilan dan postpartum. Methods : This is a cross-sectional comparative analytic study Metode: Penelitian ini merupakan studi potong lintang analitik komparatif. Results: From 28 preeclampsia subject were found, mean value of systole 165.36 mmHg and 105.71 diastole. Serum lipid profi le in pregnancy and postpartum has a signifi cant differences and correlated with preeclampsia, total cholesterol 234.5 mg/dl and 192.71 mg/dl, p=0.000; medium positive in pregnancy with systole r=0.461; p=0.013, weak positive with diastole r=0.380; p=0.046; postpartum with systole medium positive r=0.615; p=0.001, and weak positive with diastole r=0.317; p=0.100. LDL 140.5 mg/dl and 102.5 mg/ dl, p=0.000; pregnancy and systole r=0.446; p=0,017; and postpartum were medium positive r=0.546; p=0.003. HDL 51.5 mg/dl and 43.5 mg/dl, p=0.003; not correlated with BP. Triglyceride 268.89 mg/dl and 208.96 mg/dl, p=0.000; pregnancy r=0.516; p=0.005; postpartum r= 0.515; p=0.005 has medium correlation with systole. VLDL 53.78 mg/dl and 41.79, p=0.000; pregnancy r=0.461; p=0.013 systole medium positive; r=0.380; p=0.046 diastole weak positive; postpartum r=0,615; p=0,001 systole strong positive. Hasil: Dari 28 subjek dengan preeklamsia, ditemukan rerata systole 165,36 mmHg dan 105,71 diastole. Profi l lipid serum dalam kehamilan dan postpartum ditemukan berbeda bermakna dan berhubungan dengan preeklamsia berat, kolesterol total 234,5 mg/dl dan 192,71 mg/dl, p=0,000; kehamilan dengan sistole positif sedang r=0,461; p=0,013, diastole positif lemah r=0,380; p=0,046; postpartum dengan sistole positif sedang r=0,615; p=0,001, dan diastole postitif lemah r=0,317; p=0,100. LDL 140,5 mg/dl dan 102,5 mg/dl, p=0,000; dalam kehamilan dengan sistole r=0,446; p=0,017; dan postpartum positif sedang r=0,546; p=0,003. HDL 51,5 mg/dl dan 43,5 mg/dl, p=0,003; tidak berkorelasi dengan TD. Trigliserida 268,89 mg/dl dan 208,96 mg/dl, p=0,000; kehamilan r=0,516; p=0,005; postpartum r= 0,515; p = 0,005 korelasi positif sedang dengan sistole. VLDL 53,78 mg/dl dan 41,79, p=0,000; kehamilan r=0,461; p=0,013 positif sedang dengan sistole; r=0,380; p=0,046 positif lemah dengan diastole; postpartum r=0,615; p=0,001 positif kuat dengan sistole. Conclusions: All parameter of serum lipid profi le in pregnancy and postpartum had signifi cant differences and related with severe preeclampsia. Total cholesterol, LDL, triglyceride, and VLDL correlated with BP in severe preeclampsia. Kesimpulan: Seluruh parameter profi l lipid serum kehamilan dan postpartum ditemukan memiliki perbedaan bermakna dan berhubungan dengan preeklamsia berat. Kolesterol total, LDL, trigliserida, dan VLDL ditemukan berhubungan dengan TD pada PEB. Keywords: endothelial dysfunction, lipid profi le, preeclampsia. Kata kunci : disfungsi endothel, lipid, preeklamsia.